(R)-N-((2S,4R)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(3,5-dimethylisoxazol-4-yl)-4-hydroxybutan-2-yl)-2-methylpropane-2-sulfinamide

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Chemical Name:(R)-N-((2S,4R)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(3,5-dimethylisoxazol-4-yl)-4-hydroxybutan-2-yl)-2-methylpropane-2-sulfinamide
CAS No.:1616100-68-5
Molecular Formula:C₂₃H₂₈F₂N₄O₃S
Molecular Weight:478.563
Hs Code.:

Synonyms:(R)-N-((2S,4R)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(3,5-dimethylisoxazol-4-yl)-4-hydroxybutan-2-yl)-2-methylpropane-2-sulfinamide

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Chemical Property of (R)-N-((2S,4R)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(3,5-dimethylisoxazol-4-yl)-4-hydroxybutan-2-yl)-2-methylpropane-2-sulfinamide

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Technology Process of (R)-N-((2S,4R)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(3,5-dimethylisoxazol-4-yl)-4-hydroxybutan-2-yl)-2-methylpropane-2-sulfinamide

There total 11 articles about (R)-N-((2S,4R)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(3,5-dimethylisoxazol-4-yl)-4-hydroxybutan-2-yl)-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1585970-78-0
(R)-N-((S)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(3,5-dimethylisoxazol-4-yl)-4-oxobutan-2-yl)-2-methylpropane-2-sulfinamide

: 1616100-68-5
(R)-N-((2S,4R)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(3,5-dimethylisoxazol-4-yl)-4-hydroxybutan-2-yl)-2-methylpropane-2-sulfinamide

Guidance literature:: With lithium tri-t-butoxyaluminum hydride; In diethyl ether; at -78 ℃; for 0.833333h;

Reference yield:

: 1415208-99-9
2,4-difluoro-5-(pyrimidin-5-yl)benzaldehyde

: 1616100-68-5
(R)-N-((2S,4R)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(3,5-dimethylisoxazol-4-yl)-4-hydroxybutan-2-yl)-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethyl ether / 15 h / 20 - 75 °C

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C

2.2: 0.5 h / -78 - 20 °C

3.1: tetrahydrofuran / 20 h / 65 °C

4.1: n-butyllithium / tetrahydrofuran / 0.33 h / -78 °C

4.2: -78 - -40 °C

5.1: lithium tri-t-butoxyaluminum hydride / diethyl ether / 0.83 h / -78 °C

With n-butyllithium; oxalyl dichloride; dimethyl sulfoxide; lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; diethyl ether; dichloromethane;

Reference yield:

: 28342-75-8
1,5-dibromo-2,4-difluorobenzene

: 1616100-68-5
(R)-N-((2S,4R)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(3,5-dimethylisoxazol-4-yl)-4-hydroxybutan-2-yl)-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium / diethyl ether / 0.58 h / -78 °C

1.2: 0.5 h / -78 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; caesium carbonate / 1,2-dimethoxyethane; ethanol; water / 0.75 h / 100 °C

3.1: diethyl ether / 15 h / 20 - 75 °C

4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C

4.2: 0.5 h / -78 - 20 °C

5.1: tetrahydrofuran / 20 h / 65 °C

6.1: n-butyllithium / tetrahydrofuran / 0.33 h / -78 °C

6.2: -78 - -40 °C

7.1: lithium tri-t-butoxyaluminum hydride / diethyl ether / 0.83 h / -78 °C

With bis-triphenylphosphine-palladium(II) chloride; n-butyllithium; oxalyl dichloride; caesium carbonate; dimethyl sulfoxide; lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; ethanol; dichloromethane; water;