Methyl iMidazo[1,2-b]pyridazine-6-carboxylate

Base Information

• Chemical Name: Methyl iMidazo[1,2-b]pyridazine-6-carboxylate
• CAS No.: 1234616-21-7
• Molecular Formula: C₈H₇N₃O₂
• Molecular Weight: 177.162
• Hs Code.: 2933998090
• Mol file: 1234616-21-7.mol

Synonyms:

Chemical Property of Methyl iMidazo[1,2-b]pyridazine-6-carboxylate

Chemical Property:

• PKA: 3.68±0.30(Predicted)
• Density: 1.39±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

MethylImidazo[1,2-b]pyridazine-6-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl iMidazo[1,2-b]pyridazine-6-carboxylate

There total 5 articles about Methyl iMidazo[1,2-b]pyridazine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + 6-chloroimidazo[1,2-b]pyridazine (6775-78-6) → imidazo[1,2-b]pyridazine-6-carboxylic acid methyl ester (1234616-21-7)

Guidance literature:

With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; dichloro bis(acetonitrile) palladium(II); In acetonitrile; at 0 ℃; for 16h;

Reference yield:

N,N-dimethyl-formamide (68-12-2,33513-42-7) + imidazo[1,2-b]pyridazine-6-carboxylic acid (769109-13-9) → imidazo[1,2-b]pyridazine-6-carboxylic acid methyl ester (1234616-21-7)

Guidance literature:

With thionyl chloride; at 20 ℃; for 3h; Reflux;

Reference yield:

3-aminopyridazine-6-carboxylic acid (59772-58-6) → imidazo[1,2-b]pyridazine-6-carboxylic acid methyl ester (1234616-21-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol; water / 20 - 100 °C

2: thionyl chloride / 3 h / 20 °C / Reflux

With thionyl chloride; In ethanol; water;

upstream raw materials:

methanol

carbon monoxide

6-chloroimidazo[1,2-b]pyridazine

3-aminopyridazine-6-carboxylic acid

Downstream raw materials:

imidazo[1.2-b]pyridazine-6-carboxylic acid 4-(3,5-difluorobenzenesulfonyl)benzylamide

imidazo[1,2-b]pyridazine-6-carboxylic acid 4-benzenesulfonyl-benzylamide

imidazo[1,2-b]pyridazine-6-carboxylic acid

imidazo[1,2-b]pyridazine-6-carboxylic acid 4-(piperidine-1-sulfonyl)benzylamide