(7-methoxy-1,2,2-trimethyl-1,2-dihydroquinolin-4-yl)methanesulfonic acid 2,2,2-trifluoro-1-phenylethyl ester

Base Information

Chemical Name:(7-methoxy-1,2,2-trimethyl-1,2-dihydroquinolin-4-yl)methanesulfonic acid 2,2,2-trifluoro-1-phenylethyl ester
CAS No.:1345614-50-7
Molecular Formula:C₂₂H₂₄F₃NO₄S
Molecular Weight:455.498
Hs Code.:

Synonyms:(7-methoxy-1,2,2-trimethyl-1,2-dihydroquinolin-4-yl)methanesulfonic acid 2,2,2-trifluoro-1-phenylethyl ester

Suppliers and Price of (7-methoxy-1,2,2-trimethyl-1,2-dihydroquinolin-4-yl)methanesulfonic acid 2,2,2-trifluoro-1-phenylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (7-methoxy-1,2,2-trimethyl-1,2-dihydroquinolin-4-yl)methanesulfonic acid 2,2,2-trifluoro-1-phenylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (7-methoxy-1,2,2-trimethyl-1,2-dihydroquinolin-4-yl)methanesulfonic acid 2,2,2-trifluoro-1-phenylethyl ester

There total 5 articles about (7-methoxy-1,2,2-trimethyl-1,2-dihydroquinolin-4-yl)methanesulfonic acid 2,2,2-trifluoro-1-phenylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 340-04-5,340-05-6
1-phenyl-2,2,2-trifluoromethylethanol

: 1345614-49-4
(7-methoxy-1,2,2-trimethyl-1,2-dihydroquinolin-4-yl)methanesulfonyl chloride

: 1345614-50-7
(7-methoxy-1,2,2-trimethyl-1,2-dihydroquinolin-4-yl)methanesulfonic acid 2,2,2-trifluoro-1-phenylethyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1021/ol202619f

Reference yield:

: 1810-74-8
7-methoxy-2,2,4-trimethyl-1,2-dihydroquinoline

: 1345614-50-7
(7-methoxy-1,2,2-trimethyl-1,2-dihydroquinolin-4-yl)methanesulfonic acid 2,2,2-trifluoro-1-phenylethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 50 °C

2: sulfuric acid; sulfur trioxide / 20 h / 0 - 20 °C

3: phosphorus pentachloride; trichlorophosphate / 20 °C

4: triethylamine / dichloromethane / 1 h / 0 °C

With phosphorus pentachloride; sulfuric acid; sulfur trioxide; potassium carbonate; triethylamine; trichlorophosphate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol202619f

Reference yield:

: 7-methoxy-N,2,2,4-tetramethyl-1,2-dihydroquinoline

: 1345614-50-7
(7-methoxy-1,2,2-trimethyl-1,2-dihydroquinolin-4-yl)methanesulfonic acid 2,2,2-trifluoro-1-phenylethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid; sulfur trioxide / 20 h / 0 - 20 °C

2: phosphorus pentachloride; trichlorophosphate / 20 °C

3: triethylamine / dichloromethane / 1 h / 0 °C

With phosphorus pentachloride; sulfuric acid; sulfur trioxide; triethylamine; trichlorophosphate; In dichloromethane;
DOI:10.1021/ol202619f