(7-methoxy-1,2,2-trimethyl-6-(4-nitrophenylazo)-1,2-dihydroquinolin-4-yl)methanesulfonic acid 2,2,2-trifluoro-1-phenylethyl ester

Base Information

Chemical Name:(7-methoxy-1,2,2-trimethyl-6-(4-nitrophenylazo)-1,2-dihydroquinolin-4-yl)methanesulfonic acid 2,2,2-trifluoro-1-phenylethyl ester
CAS No.:1345614-52-9
Molecular Formula:C₂₈H₂₇F₃N₄O₆S
Molecular Weight:604.607
Hs Code.:

Synonyms:(7-methoxy-1,2,2-trimethyl-6-(4-nitrophenylazo)-1,2-dihydroquinolin-4-yl)methanesulfonic acid 2,2,2-trifluoro-1-phenylethyl ester

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Chemical Property of (7-methoxy-1,2,2-trimethyl-6-(4-nitrophenylazo)-1,2-dihydroquinolin-4-yl)methanesulfonic acid 2,2,2-trifluoro-1-phenylethyl ester

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Technology Process of (7-methoxy-1,2,2-trimethyl-6-(4-nitrophenylazo)-1,2-dihydroquinolin-4-yl)methanesulfonic acid 2,2,2-trifluoro-1-phenylethyl ester

There total 6 articles about (7-methoxy-1,2,2-trimethyl-6-(4-nitrophenylazo)-1,2-dihydroquinolin-4-yl)methanesulfonic acid 2,2,2-trifluoro-1-phenylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1345614-50-7
(7-methoxy-1,2,2-trimethyl-1,2-dihydroquinolin-4-yl)methanesulfonic acid 2,2,2-trifluoro-1-phenylethyl ester

: 456-27-9
4-nitrobenzenediazonium tetrafluoroborate

: 1345614-52-9
(7-methoxy-1,2,2-trimethyl-6-(4-nitrophenylazo)-1,2-dihydroquinolin-4-yl)methanesulfonic acid 2,2,2-trifluoro-1-phenylethyl ester

Guidance literature:: With sulfuric acid; In methanol; water; at 20 ℃; for 1h;
DOI:10.1021/ol202619f

Reference yield:

: 1810-74-8
7-methoxy-2,2,4-trimethyl-1,2-dihydroquinoline

: 1345614-52-9
(7-methoxy-1,2,2-trimethyl-6-(4-nitrophenylazo)-1,2-dihydroquinolin-4-yl)methanesulfonic acid 2,2,2-trifluoro-1-phenylethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 50 °C

2: sulfuric acid; sulfur trioxide / 20 h / 0 - 20 °C

3: phosphorus pentachloride; trichlorophosphate / 20 °C

4: triethylamine / dichloromethane / 1 h / 0 °C

5: sulfuric acid / methanol; water / 1 h / 20 °C

With phosphorus pentachloride; sulfuric acid; sulfur trioxide; potassium carbonate; triethylamine; trichlorophosphate; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ol202619f

Reference yield:

: 1345614-47-2
sodium (7-methoxy-1,2,2-trimethyl-1,2-dihydroquinolin-4-yl)methanesulfonate

: 1345614-52-9
(7-methoxy-1,2,2-trimethyl-6-(4-nitrophenylazo)-1,2-dihydroquinolin-4-yl)methanesulfonic acid 2,2,2-trifluoro-1-phenylethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: phosphorus pentachloride; trichlorophosphate / 20 °C

2: triethylamine / dichloromethane / 1 h / 0 °C

3: sulfuric acid / methanol; water / 1 h / 20 °C

With phosphorus pentachloride; sulfuric acid; triethylamine; trichlorophosphate; In methanol; dichloromethane; water;
DOI:10.1021/ol202619f