1-[2-(4-methoxyphenyl)ethyl]-1-azaspiro[4.5]decan-3,8-dione 8-monoethylene acetal

Base Information

Chemical Name:1-[2-(4-methoxyphenyl)ethyl]-1-azaspiro[4.5]decan-3,8-dione 8-monoethylene acetal
CAS No.:260366-82-3
Molecular Formula:C₂₀H₂₇NO₄
Molecular Weight:345.439
Hs Code.:

Synonyms:1-[2-(4-methoxyphenyl)ethyl]-1-azaspiro[4.5]decan-3,8-dione 8-monoethylene acetal

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Chemical Property of 1-[2-(4-methoxyphenyl)ethyl]-1-azaspiro[4.5]decan-3,8-dione 8-monoethylene acetal

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Technology Process of 1-[2-(4-methoxyphenyl)ethyl]-1-azaspiro[4.5]decan-3,8-dione 8-monoethylene acetal

There total 4 articles about 1-[2-(4-methoxyphenyl)ethyl]-1-azaspiro[4.5]decan-3,8-dione 8-monoethylene acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 260366-80-1
1-[2-(4-methoxyphenyl)ethyl]-3-iodo-1-azaspiro[4.5]decan-8-one ethylene acetal

: 260366-82-3
1-[2-(4-methoxyphenyl)ethyl]-1-azaspiro[4.5]decan-3,8-dione 8-monoethylene acetal

Guidance literature:: With silver tetrafluoroborate; dimethyl sulfoxide; at 20 ℃; for 12h;
DOI:10.1016/S0968-0896(99)00250-3

Reference yield:

: 55-81-2
4-Methoxyphenethylamine

: 260366-82-3
1-[2-(4-methoxyphenyl)ethyl]-1-azaspiro[4.5]decan-3,8-dione 8-monoethylene acetal

Guidance literature:: Multi-step reaction with 4 steps

1: molecular sieves / CH₂Cl₂ / 4 h / 20 °C

2: 12 g / CH₂Cl₂; diethyl ether / 4 h / 20 °C

3: 51 percent / aq. NaHCO₃; I₂ / CH₂Cl₂ / 12 h / 20 °C

4: 80 percent / AgBF₄; DMSO / 12 h / 20 °C

With silver tetrafluoroborate; molecular sieve; iodine; sodium hydrogencarbonate; dimethyl sulfoxide; In diethyl ether; dichloromethane; 1: Condensation / 2: Grignard reaction / 3: Cyclization / 4: Oxidation;
DOI:10.1016/S0968-0896(99)00250-3

Reference yield:

: 260366-92-5
(1,4-dioxa-spiro[4.5]dec-8-ylidene)-[2-(4-methoxy-phenyl)-ethyl]-amine

: 260366-82-3
1-[2-(4-methoxyphenyl)ethyl]-1-azaspiro[4.5]decan-3,8-dione 8-monoethylene acetal

Guidance literature:: Multi-step reaction with 3 steps

1: 12 g / CH₂Cl₂; diethyl ether / 4 h / 20 °C

2: 51 percent / aq. NaHCO₃; I₂ / CH₂Cl₂ / 12 h / 20 °C

3: 80 percent / AgBF₄; DMSO / 12 h / 20 °C

With silver tetrafluoroborate; iodine; sodium hydrogencarbonate; dimethyl sulfoxide; In diethyl ether; dichloromethane; 1: Grignard reaction / 2: Cyclization / 3: Oxidation;
DOI:10.1016/S0968-0896(99)00250-3