trans-3-[N-benzyl-N-(tert-butoxycarbonyl)amino]-1-[2-(4-methoxyphenyl)-ethyl]-1-azaspiro[4.5]decan-8-ol

Base Information

Chemical Name:trans-3-[N-benzyl-N-(tert-butoxycarbonyl)amino]-1-[2-(4-methoxyphenyl)-ethyl]-1-azaspiro[4.5]decan-8-ol
CAS No.:260366-87-8
Molecular Formula:C₃₀H₄₂N₂O₄
Molecular Weight:494.674
Hs Code.:

Synonyms:trans-3-[N-benzyl-N-(tert-butoxycarbonyl)amino]-1-[2-(4-methoxyphenyl)-ethyl]-1-azaspiro[4.5]decan-8-ol

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Chemical Property of trans-3-[N-benzyl-N-(tert-butoxycarbonyl)amino]-1-[2-(4-methoxyphenyl)-ethyl]-1-azaspiro[4.5]decan-8-ol

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Technology Process of trans-3-[N-benzyl-N-(tert-butoxycarbonyl)amino]-1-[2-(4-methoxyphenyl)-ethyl]-1-azaspiro[4.5]decan-8-ol

There total 10 articles about trans-3-[N-benzyl-N-(tert-butoxycarbonyl)amino]-1-[2-(4-methoxyphenyl)-ethyl]-1-azaspiro[4.5]decan-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 260366-86-7
trans-3-benzylamino-1-[2-(4-methoxyphenyl)ethyl]-1-azaspiro[4.5]decan-8-ol

: 260366-87-8
trans-3-[N-benzyl-N-(tert-butoxycarbonyl)amino]-1-[2-(4-methoxyphenyl)-ethyl]-1-azaspiro[4.5]decan-8-ol

Guidance literature:: With triethylamine; In methanol; at 50 ℃; for 5h;
DOI:10.1016/S0968-0896(99)00250-3

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 260366-87-8
trans-3-[N-benzyl-N-(tert-butoxycarbonyl)amino]-1-[2-(4-methoxyphenyl)-ethyl]-1-azaspiro[4.5]decan-8-ol

Guidance literature:: Multi-step reaction with 9 steps

1: molecular sieves / CH₂Cl₂ / 4 h / 20 °C

2: 12 g / CH₂Cl₂; diethyl ether / 4 h / 20 °C

3: 51 percent / aq. NaHCO₃; I₂ / CH₂Cl₂ / 12 h / 20 °C

4: 80 percent / AgBF₄; DMSO / 12 h / 20 °C

5: molecular sieves / CH₂Cl₂ / 4 h / 20 °C

6: 0.59 g / NaBH₄ / methanol / 0 - 20 °C

7: 79 percent / aq. HCl / tetrahydrofuran / 12 h / 20 °C

8: 75 percent / NaBH₄ / methanol / 0 - 20 °C

9: 76 percent / Et₃N / methanol / 5 h / 50 °C

With hydrogenchloride; sodium tetrahydroborate; silver tetrafluoroborate; molecular sieve; iodine; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 1: Condensation / 2: Grignard reaction / 3: Cyclization / 4: Oxidation / 5: Condensation / 6: Reduction / 7: Hydrolysis / 8: Reduction / 9: Acylation;
DOI:10.1016/S0968-0896(99)00250-3

Reference yield:

: 55-81-2
4-Methoxyphenethylamine

: 260366-87-8
trans-3-[N-benzyl-N-(tert-butoxycarbonyl)amino]-1-[2-(4-methoxyphenyl)-ethyl]-1-azaspiro[4.5]decan-8-ol

Guidance literature:: Multi-step reaction with 9 steps

1: molecular sieves / CH₂Cl₂ / 4 h / 20 °C

2: 12 g / CH₂Cl₂; diethyl ether / 4 h / 20 °C

3: 51 percent / aq. NaHCO₃; I₂ / CH₂Cl₂ / 12 h / 20 °C

4: 80 percent / AgBF₄; DMSO / 12 h / 20 °C

5: molecular sieves / CH₂Cl₂ / 4 h / 20 °C

6: 0.59 g / NaBH₄ / methanol / 0 - 20 °C

7: 79 percent / aq. HCl / tetrahydrofuran / 12 h / 20 °C

8: 75 percent / NaBH₄ / methanol / 0 - 20 °C

9: 76 percent / Et₃N / methanol / 5 h / 50 °C

With hydrogenchloride; sodium tetrahydroborate; silver tetrafluoroborate; molecular sieve; iodine; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 1: Condensation / 2: Grignard reaction / 3: Cyclization / 4: Oxidation / 5: Condensation / 6: Reduction / 7: Hydrolysis / 8: Reduction / 9: Acylation;
DOI:10.1016/S0968-0896(99)00250-3