(2E)-3-(3-methoxy-4-hydroxyphenyl)-N-hydroxy-2-propenamide

Base Information

• Chemical Name: (2E)-3-(3-methoxy-4-hydroxyphenyl)-N-hydroxy-2-propenamide
• CAS No.: 1431320-14-7
• Molecular Formula: C₁₀H₁₁NO₄
• Molecular Weight: 209.202
• Mol file: 1431320-14-7.mol

Synonyms:(2E)-3-(3-methoxy-4-hydroxyphenyl)-N-hydroxy-2-propenamide

Chemical Property of (2E)-3-(3-methoxy-4-hydroxyphenyl)-N-hydroxy-2-propenamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2E)-3-(3-methoxy-4-hydroxyphenyl)-N-hydroxy-2-propenamide

There total 5 articles about (2E)-3-(3-methoxy-4-hydroxyphenyl)-N-hydroxy-2-propenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

Methyl ferulate (2309-07-1) → (2E)-3-(3-methoxy-4-hydroxyphenyl)-N-hydroxy-2-propenamide (1431320-14-7)

Guidance literature:

With hydroxylamine hydrochloride; sodium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 24h;

DOI:10.1002/cmdc.202000084

Reference yield:

C15H19NO5 → (2E)-3-(3-methoxy-4-hydroxyphenyl)-N-hydroxy-2-propenamide (1431320-14-7)

Guidance literature:

With hydrogenchloride; In methanol; water; at 20 - 70 ℃;

DOI:10.1002/cmdc.201800238

Reference yield:

trans-4-hydroxy-3-methoxycinnamic acid chloride (138769-50-3,108608-04-4) → (2E)-3-(3-methoxy-4-hydroxyphenyl)-N-hydroxy-2-propenamide (1431320-14-7)

Guidance literature:

With hydroxylamine hydrochloride; sodium hydroxide; In diethyl ether; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1002/cmdc.202000084

upstream raw materials:

(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid

vanillin

Methyl ferulate

trans-4-hydroxy-3-methoxycinnamic acid chloride