(R)-5-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Base Information

Chemical Name:(R)-5-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS No.:1364889-40-6
Molecular Formula:C₁₇H₁₄F₃N₅O
Molecular Weight:361.326
Hs Code.:

Synonyms:(R)-5-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

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Chemical Property of (R)-5-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

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Technology Process of (R)-5-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

There total 11 articles about (R)-5-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1364890-54-9
(R)-5-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

: 1364889-40-6
(R)-5-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: (R)-5-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 0.5h;

With ammonium hydroxide; ammonium chloride; In 1-methyl-pyrrolidin-2-one; for 1h;

Reference yield:

: 1223405-20-6
(R)-4,4-difluoro-2-(3-fluorophenyl)pyrrolidine

: 1364890-20-9
5-chloropyrazolo[1,5-a]pyrimidine-3-carboxamide

: 1364889-40-6
(R)-5-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: With potassium fluoride; In dimethyl sulfoxide; at 85 ℃; for 2h;

Reference yield:

: 1364889-98-4
tert-butyl (2R)-2-(tert-butyldimethylsilyloxy)-4-(3-fluorophenyl)-4-hydroxybutylcarbamate

: 1364889-40-6
(R)-5-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; methanesulfonyl chloride / dichloromethane / 1 h / -60 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

2.2: 20 °C

3.1: trichloroisocyanuric acid / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 1.25 h / -10 - 20 °C

4.1: diethylamino-sulfur trifluoride / dichloromethane / 2.5 h / -78 - 20 °C / Plastic bottle

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5.2: 0 °C

6.1: potassium fluoride / dimethyl sulfoxide / 2 h / 85 °C

With potassium fluoride; diethylamino-sulfur trifluoride; trichloroisocyanuric acid; tetrabutyl ammonium fluoride; methanesulfonyl chloride; triethylamine; trifluoroacetic acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;