7,8-dihydro-7-methyl-5-(4-methylphenyl)-8-oxo-6-pyrido<3,4-b>pyridinecarboxaldehyde

Base Information

Chemical Name:7,8-dihydro-7-methyl-5-(4-methylphenyl)-8-oxo-6-pyrido<3,4-b>pyridinecarboxaldehyde
CAS No.:168543-07-5
Molecular Formula:C₁₇H₁₄N₂O₂
Molecular Weight:278.31
Hs Code.:

Synonyms:7,8-dihydro-7-methyl-5-(4-methylphenyl)-8-oxo-6-pyrido<3,4-b>pyridinecarboxaldehyde

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Chemical Property of 7,8-dihydro-7-methyl-5-(4-methylphenyl)-8-oxo-6-pyrido<3,4-b>pyridinecarboxaldehyde

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Technology Process of 7,8-dihydro-7-methyl-5-(4-methylphenyl)-8-oxo-6-pyrido<3,4-b>pyridinecarboxaldehyde

There total 5 articles about 7,8-dihydro-7-methyl-5-(4-methylphenyl)-8-oxo-6-pyrido<3,4-b>pyridinecarboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 168543-06-4
N-(formylmethyl)-N-methyl-3-(4-methylbenzoyl)-2-pyridinecarboxamide

: 168543-07-5
7,8-dihydro-7-methyl-5-(4-methylphenyl)-8-oxo-6-pyrido<3,4-b>pyridinecarboxaldehyde

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; for 0.5h; Heating;
DOI:10.1021/jm00016a014

Reference yield:

: 699-98-9
Pyridine-2,3-dicarboxylic anhydride

: 168543-07-5
7,8-dihydro-7-methyl-5-(4-methylphenyl)-8-oxo-6-pyrido<3,4-b>pyridinecarboxaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 63 percent / AlCl₃ / 4 h / Heating

2: SOCl₂, DMF / tetrahydrofuran / 3.5 h / Heating

3: Et₃N / CH₂Cl₂ / 15 h / Ambient temperature

4: 78 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / toluene / 0.5 h / Heating

With aluminium trichloride; thionyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jm00016a014

Reference yield:

: 116060-91-4
3-(4-methylbenzoyl)-2-pyridine carboxylic acid

: 168543-07-5
7,8-dihydro-7-methyl-5-(4-methylphenyl)-8-oxo-6-pyrido<3,4-b>pyridinecarboxaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂, DMF / tetrahydrofuran / 3.5 h / Heating

2: Et₃N / CH₂Cl₂ / 15 h / Ambient temperature

3: 78 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / toluene / 0.5 h / Heating

With thionyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jm00016a014