Benzyl 5-methyl-2,4-dioxo-3-phenylamino-1,3-oxazolidine-5-carboxylate

Base Information

• Chemical Name: Benzyl 5-methyl-2,4-dioxo-3-phenylamino-1,3-oxazolidine-5-carboxylate
• CAS No.: 233274-28-7
• Molecular Formula: C₁₈H₁₆N₂O₅
• Molecular Weight: 340.335
• Mol file: 233274-28-7.mol

Synonyms:Benzyl 5-methyl-2,4-dioxo-3-phenylamino-1,3-oxazolidine-5-carboxylate

Chemical Property of Benzyl 5-methyl-2,4-dioxo-3-phenylamino-1,3-oxazolidine-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzyl 5-methyl-2,4-dioxo-3-phenylamino-1,3-oxazolidine-5-carboxylate

There total 3 articles about Benzyl 5-methyl-2,4-dioxo-3-phenylamino-1,3-oxazolidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

phenylhydrazine (100-63-0) + 2-methyl-2-([1,2,4]triazole-1-carbonyloxy)-malonic acid dibenzyl ester → Benzyl 5-methyl-2,4-dioxo-3-phenylamino-1,3-oxazolidine-5-carboxylate (233274-28-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 40h;

DOI:10.1515/znb-1999-0516

Reference yield:

benzyl bromide (100-39-0) → Benzyl 5-methyl-2,4-dioxo-3-phenylamino-1,3-oxazolidine-5-carboxylate (233274-28-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent / (i-Pr)2NEt / N,N-dimethyl-acetamide / 24 h / 20 °C

2: Et₃N / CH₂Cl₂ / 1 h / 20 °C

3: 63 percent / Et₃N / CH₂Cl₂ / 40 h / 20 °C

With triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl acetamide; 1: Esterification / 2: Acylation / 3: Acylation;

DOI:10.1515/znb-1999-0516

Reference yield:

dibenzyl 2-hydroxy-2-methylmalonate (233274-19-6) → Benzyl 5-methyl-2,4-dioxo-3-phenylamino-1,3-oxazolidine-5-carboxylate (233274-28-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 1 h / 20 °C

2: 63 percent / Et₃N / CH₂Cl₂ / 40 h / 20 °C

With triethylamine; In dichloromethane; 1: Acylation / 2: Acylation;

DOI:10.1515/znb-1999-0516

upstream raw materials:

phenylhydrazine

benzyl bromide

dibenzyl 2-hydroxy-2-methylmalonate