2,2,2-trifluoroethyl 5-(4-fluorophenyl)-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydropyridine-3-carboxylate

Base Information

Chemical Name:2,2,2-trifluoroethyl 5-(4-fluorophenyl)-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydropyridine-3-carboxylate
CAS No.:1449300-95-1
Molecular Formula:C₁₆H₁₀F₇NO₃
Molecular Weight:397.249
Hs Code.:

Synonyms:2,2,2-trifluoroethyl 5-(4-fluorophenyl)-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydropyridine-3-carboxylate

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Chemical Property of 2,2,2-trifluoroethyl 5-(4-fluorophenyl)-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydropyridine-3-carboxylate

Chemical Property:

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Technology Process of 2,2,2-trifluoroethyl 5-(4-fluorophenyl)-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydropyridine-3-carboxylate

There total 1 articles about 2,2,2-trifluoroethyl 5-(4-fluorophenyl)-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydropyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1052114-81-4
5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridin-3-ylcarboxylic acid

: 6226-25-1
2,2,2-trifluoroethyl trifluoromethanesulphonate

: 1449300-95-1
2,2,2-trifluoroethyl 5-(4-fluorophenyl)-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydropyridine-3-carboxylate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 67-56-1
methanol

: 1449300-95-1
2,2,2-trifluoroethyl 5-(4-fluorophenyl)-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydropyridine-3-carboxylate

: C₁₇H₁₃F₆NO₄

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 20 - 80 ℃;

Reference yield:

: 1449300-95-1
2,2,2-trifluoroethyl 5-(4-fluorophenyl)-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydropyridine-3-carboxylate

: 1449300-96-2
1-(2,2-difluoro-2-methoxyethyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water; tetrahydrofuran / 20 - 80 °C

2: sodium hydroxide; water / tetrahydrofuran

With water; sodium hydroxide; In tetrahydrofuran; water;