methyl 4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate

Base Information

Chemical Name:methyl 4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate
CAS No.:913078-73-6
Molecular Formula:C₂₅H₂₆F₃NO₆S
Molecular Weight:525.546
Hs Code.:

Synonyms:methyl 4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate

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Technology Process of methyl 4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate

There total 8 articles about methyl 4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 913078-72-5
methyl 4-{[2-{[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate

: 513-38-2
Isobutyl iodide

: 913078-73-6
methyl 4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃;
DOI:10.1016/j.bmc.2006.06.067

Reference yield:

: 534-22-5
2-methylfuran

: 913078-73-6
methyl 4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / acetonitrile / 23 h / 40 °C

2: 41 percent / oxalyl chloride / 1,2-dimethoxy-ethane; dimethylformamide / 3 h / 20 °C

3: 80 percent / pyridine / CH₂Cl₂ / 9 h

4: 94 percent / potassium carbonate / dimethylformamide / 80 °C

With pyridine; oxalyl dichloride; potassium carbonate; In 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2006.06.067

Reference yield:

: 907587-49-9
methyl 4-[(2-amino-5-(trifluoromethyl)phenoxy)methyl]benzoate

: 913078-73-6
methyl 4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / pyridine / CH₂Cl₂ / 9 h

2: 94 percent / potassium carbonate / dimethylformamide / 80 °C

With pyridine; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.06.067