Technology Process of 2-methyl-3-nitro-benzaldehyde dimethylacetal
There total 2 articles about 2-methyl-3-nitro-benzaldehyde dimethylacetal which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
thionyl chloride;
1.) dry ice/ethanol bath, 2.) room temp., 1 h;
DOI:10.1021/jo00321a053
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 52.5 percent / CrO3, H2SO4, AcOH / 0.5 h / 5 - 10 °C
2: 95 percent / thionyl chloride / 1.) dry ice/ethanol bath, 2.) room temp., 1 h
With
chromium(VI) oxide; thionyl chloride; sulfuric acid; acetic acid;
DOI:10.1021/jo00321a053
- Guidance literature:
-
Multi-step reaction with 6 steps
1: H2O
2: 96.5 percent / BF3*Et2O / CHCl3 / 0.5 h / Ambient temperature
3: 1) pyrrolidine, 2) hydrazine hydrate / 2) Raney-Ni / 1) DMF, 135 deg C, 3h, 2) THF/MeOH, 2-propanol, 50 deg C, 3h
4: 1) NaOMe / 1) Et2O, 1h, 2) overnight, r.t.
5: 120 mg / H2 / Pd/C / methanol; CH2Cl2 / 0.75 h / 760 Torr / Ambient temperature
6: 89 percent / NaBH4 / 1) r.t., 1h, 2) 60 - 70 deg C
With
pyrrolidine; sodium tetrahydroborate; water; hydrogen; sodium methylate; hydrazine hydrate;
palladium on activated charcoal; boron trifluoride diethyl etherate; nickel;
In
methanol; dichloromethane; chloroform;
DOI:10.1002/ardp.19903230305
