7-methyl-2-morpholino-9-(1-(phenylamino)ethyl)-4H-pyrido[1,2-a]pyrimidin-4-one

Base Information

Chemical Name:7-methyl-2-morpholino-9-(1-(phenylamino)ethyl)-4H-pyrido[1,2-a]pyrimidin-4-one
CAS No.:663619-89-4
Molecular Formula:C21H24N4O2
Molecular Weight:364.447
Hs Code.:
UNII:6L28AW98TH
DSSTox Substance ID:DTXSID101025688
Nikkaji Number:J2.482.106D
Wikidata:Q27088979
Pharos Ligand ID:6CK9SU9D3HKG
ChEMBL ID:CHEMBL1972466
Mol file:663619-89-4.mol

Synonyms:TGX 221;TGX-221;TGX221 cpd

Suppliers and Price of 7-methyl-2-morpholino-9-(1-(phenylamino)ethyl)-4H-pyrido[1,2-a]pyrimidin-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
TGX-221
10mg
$ 165.00

Tocris
TGX221 ≥98%(HPLC)
50
$ 1206.00

Tocris
TGX221 ≥98%(HPLC)
10
$ 287.00

Sigma-Aldrich
PI 3-Kβ Inhibitor VI, TGX-221 - CAS 663619-89-4 - Calbiochem
1mg
$ 326.00

Medical Isotopes, Inc.
TGX-221
1 mg
$ 190.00

DC Chemicals
TGX221 >98%
1 g
$ 1400.00

Crysdot
TGX-221 98+%
50mg
$ 336.00

Crysdot
TGX-221 98+%
100mg
$ 511.00

ChemScene
TGX-221 99.65%
50mg
$ 420.00

ChemScene
TGX-221 99.65%
100mg
$ 660.00

Total 41 raw suppliers

Chemical Property of 7-methyl-2-morpholino-9-(1-(phenylamino)ethyl)-4H-pyrido[1,2-a]pyrimidin-4-one

Chemical Property:

Boiling Point:557.293 °C at 760 mmHg
PKA:3.90±0.50(Predicted)
Flash Point:290.841 °C
PSA：58.87000
Density:1.259 g/cm³
LogP:3.15060
Storage Temp.:Hygroscopic, Refrigerator, under inert atmosphere
Solubility.:DMSO (Slightly), Methanol (Very Slightly)
XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:364.18992602
Heavy Atom Count:27
Complexity:710

Purity/Quality:

99%, ^*data from raw suppliers

TGX-221 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CN2C(=O)C=C(N=C2C(=C1)C(C)NC3=CC=CC=C3)N4CCOCC4
Uses TGX-221 is a potent, selective, and cell permeable inhibitor of Phosphatidylinositol 3-kinase (PI3K) p110β.

Technology Process of 7-methyl-2-morpholino-9-(1-(phenylamino)ethyl)-4H-pyrido[1,2-a]pyrimidin-4-one

There total 11 articles about 7-methyl-2-morpholino-9-(1-(phenylamino)ethyl)-4H-pyrido[1,2-a]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 9-acetyl-7-methyl-2-(morpholin-4-yl)-4H-pyrido[1,2-a]pyrimidin-4-one

: 62-53-3
aniline

: 663619-89-4
7-methyl-2-(4-morpholinyl)-9-[1-(phenylamino)ethyl]-4H-pyrido[1,2-a]pyrimidin-4-one

Guidance literature:: 9-acetyl-7-methyl-2-(morpholin-4-yl)-4H-pyrido[1,2-a]pyrimidin-4-one; aniline; In toluene; for 4h; Heating / reflux;

With sodium tetrahydroborate; In toluene; at 0 - 20 ℃; for 1h;

Reference yield:

: C₂₁H₂₂N₄O₂

: 663619-89-4
7-methyl-2-(4-morpholinyl)-9-[1-(phenylamino)ethyl]-4H-pyrido[1,2-a]pyrimidin-4-one

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 1h;
DOI:10.1021/mp200007b

Reference yield:

: 17282-00-7
3-bromo-5-methylpyridin-2-amine

: 663619-89-4
7-methyl-2-(4-morpholinyl)-9-[1-(phenylamino)ethyl]-4H-pyrido[1,2-a]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: dichloromethane / 20 °C

2.1: methanesulfonyl chloride; triethylamine

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-ethyl-N,N-diisopropylamine

3.2: 20 °C

4.1: toluene / 4 h / Reflux; Molecular sieve; Inert atmosphere

5.1: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; toluene;
DOI:10.1021/mp200007b