N-(3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)oxirane-2-carboxamide

Base Information

Chemical Name:N-(3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)oxirane-2-carboxamide
CAS No.:1616380-43-8
Molecular Formula:C₂₂H₂₂FN₅O₄
Molecular Weight:439.446
Hs Code.:

Synonyms:N-(3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)oxirane-2-carboxamide

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Chemical Property of N-(3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)oxirane-2-carboxamide

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Technology Process of N-(3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)oxirane-2-carboxamide

There total 12 articles about N-(3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)oxirane-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616380-55-2
3-((3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)amino)-2-hydroxy-3-oxopropyl methanesulfonate

: 1616380-43-8
N-(3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)oxirane-2-carboxamide

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.75h; Inert atmosphere;

Reference yield:

: 1202759-89-4
tert-butyl (3-((2-chloro-5-fluoropyrimidin-4-yl)amino)phenyl)carbamate

: 1616380-43-8
N-(3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)oxirane-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: toluene-4-sulfonic acid / ethanol / 24 h / Reflux

2: trifluoroacetic acid / dichloromethane / 0.75 h / 0 °C

3: dichloromethane / -30 °C

4: 4-methylmorpholine N-oxide; osmium(VIII) oxide / water; tetrahydrofuran / 20 °C

5: triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

6: sodium hydride / tetrahydrofuran / 0.75 h / 0 - 20 °C / Inert atmosphere

With osmium(VIII) oxide; sodium hydride; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water;

Reference yield:

: 68621-88-5
(3-aminophenyl)carbamic acid tert-butyl ester

: 1616380-43-8
N-(3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)oxirane-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Reflux

2: acetic acid / tert-Amyl alcohol / 4 h / Reflux

3: dichloromethane / 0.67 h / -30 °C

4: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; tetrahydrofuran / 20 °C

5: triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

6: sodium hydride / tetrahydrofuran / 0.75 h / 0 - 20 °C / Inert atmosphere

With osmium(VIII) oxide; sodium hydride; acetic acid; 4-methylmorpholine N-oxide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; tert-Amyl alcohol; dichloromethane; water;