3-((3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)amino)-2-hydroxy-3-oxopropyl methanesulfonate

Base Information

Chemical Name:3-((3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)amino)-2-hydroxy-3-oxopropyl methanesulfonate
CAS No.:1616380-55-2
Molecular Formula:C₂₃H₂₆FN₅O₇S
Molecular Weight:535.553
Hs Code.:

Synonyms:3-((3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)amino)-2-hydroxy-3-oxopropyl methanesulfonate

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Chemical Property of 3-((3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)amino)-2-hydroxy-3-oxopropyl methanesulfonate

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Technology Process of 3-((3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)amino)-2-hydroxy-3-oxopropyl methanesulfonate

There total 11 articles about 3-((3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)amino)-2-hydroxy-3-oxopropyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-(3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-2,3-dihydroxypropanamide

: 124-63-0
methanesulfonyl chloride

: 1616380-55-2
3-((3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)amino)-2-hydroxy-3-oxopropyl methanesulfonate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1202759-89-4
tert-butyl (3-((2-chloro-5-fluoropyrimidin-4-yl)amino)phenyl)carbamate

: 1616380-55-2
3-((3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)amino)-2-hydroxy-3-oxopropyl methanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / ethanol / 24 h / Reflux

2: trifluoroacetic acid / dichloromethane / 0.75 h / 0 °C

3: dichloromethane / -30 °C

4: 4-methylmorpholine N-oxide; osmium(VIII) oxide / water; tetrahydrofuran / 20 °C

5: triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

With osmium(VIII) oxide; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water;

Reference yield:

: 68621-88-5
(3-aminophenyl)carbamic acid tert-butyl ester

: 1616380-55-2
3-((3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)amino)-2-hydroxy-3-oxopropyl methanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Reflux

2: acetic acid / tert-Amyl alcohol / 4 h / Reflux

3: dichloromethane / 0.67 h / -30 °C

4: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; tetrahydrofuran / 20 °C

5: triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

With osmium(VIII) oxide; acetic acid; 4-methylmorpholine N-oxide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; tert-Amyl alcohol; dichloromethane; water;