acetic acid 2-(6-tert-butyl-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-6-chlorobenzyl ester

Base Information

Chemical Name:acetic acid 2-(6-tert-butyl-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-6-chlorobenzyl ester
CAS No.:1612853-72-1
Molecular Formula:C₂₂H₂₄ClNO₃
Molecular Weight:385.89
Hs Code.:

Synonyms:acetic acid 2-(6-tert-butyl-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-6-chlorobenzyl ester

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Chemical Property of acetic acid 2-(6-tert-butyl-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-6-chlorobenzyl ester

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Technology Process of acetic acid 2-(6-tert-butyl-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-6-chlorobenzyl ester

There total 4 articles about acetic acid 2-(6-tert-butyl-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-6-chlorobenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1462328-88-6
6-tert-butyl-2-(3-chloro-2-hydroxymethylphenyl)-3,4-dihydro-2H-isoquinolin-1-one

: 108-24-7
acetic anhydride

: 1612853-72-1
acetic acid 2-(6-tert-butyl-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-6-chlorobenzyl ester

Guidance literature:: With pyridine; In dichloromethane;

Reference yield:

: 64622-16-8
2-bromo-6-chlorobenzaldehyde

: 1612853-72-1
acetic acid 2-(6-tert-butyl-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-6-chlorobenzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: palladium diacetate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / N,N-dimethyl-formamide / 16.5 h / 90 °C / Inert atmosphere

2: sodium tetrahydroborate; isopropyl alcohol / dichloromethane / 1.25 h / 2 - 9 °C

3: pyridine / dichloromethane

With pyridine; sodium tetrahydroborate; palladium diacetate; potassium carbonate; isopropyl alcohol; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1612853-69-6
2-(6-tert-butyl-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)-6-chlorobenzaldehyde

: 1612853-72-1
acetic acid 2-(6-tert-butyl-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-6-chlorobenzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate; isopropyl alcohol / dichloromethane / 1.25 h / 2 - 9 °C

2: pyridine / dichloromethane

With pyridine; sodium tetrahydroborate; isopropyl alcohol; In dichloromethane;