1-{4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-phenyl}-ethanone

Base Information

Chemical Name:1-{4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-phenyl}-ethanone
CAS No.:1233037-18-7
Molecular Formula:C₁₉H₁₄Cl₂F₃NO₂
Molecular Weight:416.227
Hs Code.:

Synonyms:1-{4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-phenyl}-ethanone

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Chemical Property of 1-{4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-phenyl}-ethanone

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Technology Process of 1-{4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-phenyl}-ethanone

There total 5 articles about 1-{4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-phenyl}-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1353046-19-1
1-{4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-phenyl}-ethanol

: 1233037-18-7
1-{4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-phenyl}-ethanone

Guidance literature:: 1-{4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-phenyl}-ethanol; With Dess-Martin periodane; In dichloromethane; at 20 ℃;

With sodium hydrogencarbonate; In dichloromethane; water; at 20 ℃; for 1h;

Reference yield: 60.0%

: 5-(3,5-dichloro-phenyl)-3-(4-bromo-3-methyl-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazole

: 17832-28-9
4-(vinyloxy)butan-1-ol

: 1233037-18-7
1-{4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-phenyl}-ethanone

Guidance literature:: 5-(3,5-dichloro-phenyl)-3-(4-bromo-3-methyl-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazole; 4-(vinyloxy)butan-1-ol; With N-cyclohexyl-cyclohexanamine; 1% Pd/C; 1,3-bis-(diphenylphosphino)propane; In butan-1-ol; Reflux;

With acetic acid; In water; ethyl acetate; butan-1-ol; at 20 ℃; for 1h;

Reference yield: 60.0%

: 5-(3,5-dichloro-phenyl)-3-(4-bromo-3-methyl-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazole

: 141-78-6
ethyl acetate

: 1233037-18-7
1-{4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-phenyl}-ethanone

Guidance literature:: 5-(3,5-dichloro-phenyl)-3-(4-bromo-3-methyl-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazole; With 4-(vinyloxy)butan-1-ol; N-Methyldicyclohexylamine; palladium 10% on activated carbon; 1,3-bis-(diphenylphosphino)propane; In butan-1-ol; Inert atmosphere; Reflux;

ethyl acetate; With hydrogenchloride; In water; butan-1-ol; at 20 ℃; for 1h;