4-(4-(acryloyloxymethyl)-2-methoxy-5-nitrophenoxy)butanoic acid

Base Information

• Chemical Name: 4-(4-(acryloyloxymethyl)-2-methoxy-5-nitrophenoxy)butanoic acid
• CAS No.: 1392043-87-6
• Molecular Formula: C₁₅H₁₇NO₈
• Molecular Weight: 339.302
• Mol file: 1392043-87-6.mol

Synonyms:4-(4-(acryloyloxymethyl)-2-methoxy-5-nitrophenoxy)butanoic acid

Chemical Property of 4-(4-(acryloyloxymethyl)-2-methoxy-5-nitrophenoxy)butanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-(acryloyloxymethyl)-2-methoxy-5-nitrophenoxy)butanoic acid

There total 5 articles about 4-(4-(acryloyloxymethyl)-2-methoxy-5-nitrophenoxy)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-(4-(hydroxymethyl)-2-methoxy-5-nitrophenoxy)butanoic acid (355017-64-0) + acryloyl chloride (814-68-6,25189-84-8) → 4-(4-(acryloyloxymethyl)-2-methoxy-5-nitrophenoxy)butanoic acid (1392043-87-6)

Guidance literature:

4-(4-(hydroxymethyl)-2-methoxy-5-nitrophenoxy)butanoic acid; acryloyl chloride; With triethylamine; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

In water; for 3h; Inert atmosphere;

DOI:10.1021/ja305280w

Reference yield:

vanillin (121-33-5,8014-42-4) → 4-(4-(acryloyloxymethyl)-2-methoxy-5-nitrophenoxy)butanoic acid (1392043-87-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

2.1: nitric acid / 0 - 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / water / 3 h / 90 °C / Inert atmosphere

4.1: sodium tetrahydroborate / 12 h / 0 - 20 °C / Inert atmosphere

5.1: triethylamine / tetrahydrofuran / 0 °C / Inert atmosphere

5.2: 3 h / Inert atmosphere

With sodium tetrahydroborate; nitric acid; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.1021/ja305280w

Reference yield:

4-(4-formyl-2-methoxy-5-nitrophenoxy)butanoic acid (263758-69-6) → 4-(4-(acryloyloxymethyl)-2-methoxy-5-nitrophenoxy)butanoic acid (1392043-87-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / 12 h / 0 - 20 °C / Inert atmosphere

2.1: triethylamine / tetrahydrofuran / 0 °C / Inert atmosphere

2.2: 3 h / Inert atmosphere

With sodium tetrahydroborate; triethylamine; In tetrahydrofuran;

DOI:10.1021/ja305280w

upstream raw materials:

4-(4-(hydroxymethyl)-2-methoxy-5-nitrophenoxy)butanoic acid

acryloyl chloride

vanillin

4-(4-formyl-2-methoxy-5-nitrophenoxy)butanoic acid