5-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine-3-carbaldehyde

Base Information

Chemical Name:5-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine-3-carbaldehyde
CAS No.:1060725-77-0
Molecular Formula:C₂₂H₂₄Cl₂N₄O₂
Molecular Weight:447.364
Hs Code.:

Synonyms:5-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine-3-carbaldehyde

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Chemical Property of 5-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine-3-carbaldehyde

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Technology Process of 5-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine-3-carbaldehyde

There total 6 articles about 5-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1060725-03-2
5-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 1060725-77-0
5-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine-3-carbaldehyde

Guidance literature:: 5-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine; N,N-dimethyl-formamide; With trichlorophosphate; at 20 ℃; for 1h;

With sodium hydroxide; In water; N,N-dimethyl-formamide;

Reference yield:

: 156969-42-5
pyrazolo<1,5-a>pyridin-5-ol

: 1060725-77-0
5-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine-3-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C / Inert atmosphere

2.1: sodium iodide / acetonitrile / 0.5 h / Reflux; Inert atmosphere

2.2: 5 h / 85 °C / Inert atmosphere

3.1: trichlorophosphate / 1 h / 20 °C / Inert atmosphere

3.2: Cooling; Inert atmosphere

With potassium carbonate; sodium iodide; trichlorophosphate; In N,N-dimethyl-formamide; acetonitrile; 3.1: |Vilsmeier Reaction / 3.2: |Vilsmeier Reaction;
DOI:10.1021/jm5004039

Reference yield:

: 620-08-6,1232006-56-2
4-methoxypyridine

: 1060725-77-0
5-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine-3-carbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1.1: 20 h / 20 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: hydrogen bromide / 16 h / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C / Inert atmosphere

5.1: sodium iodide / acetonitrile / 0.5 h / Reflux; Inert atmosphere

5.2: 5 h / 85 °C / Inert atmosphere

6.1: trichlorophosphate / 1 h / 20 °C / Inert atmosphere

6.2: Cooling; Inert atmosphere

With hydrogen bromide; potassium carbonate; sodium iodide; trichlorophosphate; In N,N-dimethyl-formamide; acetonitrile; 6.1: |Vilsmeier Reaction / 6.2: |Vilsmeier Reaction;
DOI:10.1021/jm5004039