2-chloro-5-fluoro-N₄-[4-(prop-2-ynyloxy)phenyl]-4-pyrimidineamine

Base Information

• Chemical Name: 2-chloro-5-fluoro-N₄-[4-(prop-2-ynyloxy)phenyl]-4-pyrimidineamine
• CAS No.: 916738-12-0
• Molecular Formula: C₁₃H₉ClFN₃O
• Molecular Weight: 277.685
• Mol file: 916738-12-0.mol

Synonyms:2-chloro-5-fluoro-N₄-[4-(prop-2-ynyloxy)phenyl]-4-pyrimidineamine

Chemical Property of 2-chloro-5-fluoro-N₄-[4-(prop-2-ynyloxy)phenyl]-4-pyrimidineamine

Chemical Property:

• Boiling Point: 447.8±45.0 °C(Predicted)
• Density: 1.396±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-5-fluoro-N₄-[4-(prop-2-ynyloxy)phenyl]-4-pyrimidineamine

There total 2 articles about 2-chloro-5-fluoro-N₄-[4-(prop-2-ynyloxy)phenyl]-4-pyrimidineamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(prop-2-ynyloxy)aniline (26557-78-8) + 2,4-dichloro-5-fluoropyrimidine (2927-71-1) → 2-chloro-5-fluoro-N4-[4-(prop-2-ynyloxy)phenyl]-4-pyrimidineamine (916738-12-0)

Guidance literature:

In methanol; water; at 20 ℃; for 18h;

Reference yield:

1-nitro-4-(prop-2-ynyloxy)benzene (17061-85-7) → 2-chloro-5-fluoro-N4-[4-(prop-2-ynyloxy)phenyl]-4-pyrimidineamine (916738-12-0)

Guidance literature:

Multi-step reaction with 2 steps

1: iron; ammonium chloride; water / ethanol / 0.25 h / 70 °C

2: methanol; water / 18 h / 20 °C

With water; iron; ammonium chloride; In methanol; ethanol; water;

Reference yield:

2-chloro-5-fluoro-N4-[4-(prop-2-ynyloxy)phenyl]-4-pyrimidineamine (916738-12-0) + 5-amino-2-methylbenzenesulfonamide (6973-09-7) → N2-(3-aminosulfonyl-4-methylphenyl)-5-fluoro-N4-[4-(prop-2-ynyloxy)phenyl]-2,4-pyrimidinediamine

Guidance literature:

With trifluoroacetic acid; In isopropyl alcohol; at 100 ℃; for 3h; Sealed vial;

upstream raw materials:

4-(prop-2-ynyloxy)aniline

2,4-dichloro-5-fluoropyrimidine

1-nitro-4-(prop-2-ynyloxy)benzene