Technology Process of 2-((2-amino-5-(benzyloxy)phenyl)ethynyl)-3,4-diisobutoxybenzoic acid
There total 13 articles about 2-((2-amino-5-(benzyloxy)phenyl)ethynyl)-3,4-diisobutoxybenzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
water;
In
tetrahydrofuran; methanol; water;
at 20 ℃;
Inert atmosphere;
DOI:10.1021/ol401197n
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tin(II) chloride dihdyrate / ethyl acetate / 50 °C / Inert atmosphere
2.1: triphenylphosphine; copper(l) iodide; triethylamine / toluene / 0.08 h / 20 °C / Inert atmosphere
2.2: 1 h / 110 °C / Inert atmosphere; Microwave irradiation
3.1: potassium carbonate / methanol / 0.5 h / 20 °C / Inert atmosphere
4.1: triphenylphosphine; copper(l) iodide; triethylamine / toluene / 0.08 h / 20 °C / Inert atmosphere
4.2: 1 h / 110 °C / Inert atmosphere; Microwave irradiation
5.1: water / water; methanol; tetrahydrofuran / 20 °C / Inert atmosphere
With
copper(l) iodide; tin(II) chloride dihdyrate; water; potassium carbonate; triethylamine; triphenylphosphine;
In
tetrahydrofuran; methanol; water; ethyl acetate; toluene;
DOI:10.1021/ol401197n
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triphenylphosphine; copper(l) iodide; triethylamine / toluene / 0.08 h / 20 °C / Inert atmosphere
1.2: 1 h / 110 °C / Inert atmosphere; Microwave irradiation
2.1: potassium carbonate / methanol / 0.5 h / 20 °C / Inert atmosphere
3.1: triphenylphosphine; copper(l) iodide; triethylamine / toluene / 0.08 h / 20 °C / Inert atmosphere
3.2: 1 h / 110 °C / Inert atmosphere; Microwave irradiation
4.1: water / water; methanol; tetrahydrofuran / 20 °C / Inert atmosphere
With
copper(l) iodide; water; potassium carbonate; triethylamine; triphenylphosphine;
In
tetrahydrofuran; methanol; water; toluene;
DOI:10.1021/ol401197n
