methyl 2-((2-amino-5-(benzyloxy)phenyl)ethynyl)-3,4-diisobutoxybenzoate

Base Information

Chemical Name:methyl 2-((2-amino-5-(benzyloxy)phenyl)ethynyl)-3,4-diisobutoxybenzoate
CAS No.:1440546-86-0
Molecular Formula:C₃₁H₃₅NO₅
Molecular Weight:501.623
Hs Code.:

Synonyms:methyl 2-((2-amino-5-(benzyloxy)phenyl)ethynyl)-3,4-diisobutoxybenzoate

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Chemical Property of methyl 2-((2-amino-5-(benzyloxy)phenyl)ethynyl)-3,4-diisobutoxybenzoate

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Technology Process of methyl 2-((2-amino-5-(benzyloxy)phenyl)ethynyl)-3,4-diisobutoxybenzoate

There total 13 articles about methyl 2-((2-amino-5-(benzyloxy)phenyl)ethynyl)-3,4-diisobutoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1440546-83-7
4-(benzyloxy)-2-ethynylaniline

: 1440546-85-9
methyl 2-iodo-3,4-diisobutoxybenzoate

: 1440546-86-0
methyl 2-((2-amino-5-(benzyloxy)phenyl)ethynyl)-3,4-diisobutoxybenzoate

Guidance literature:: 4-(benzyloxy)-2-ethynylaniline; With copper(l) iodide; triethylamine; triphenylphosphine; In toluene; at 20 ℃; for 0.0833333h; Inert atmosphere;

methyl 2-iodo-3,4-diisobutoxybenzoate; With bis-triphenylphosphine-palladium(II) chloride; triethylamine; In toluene; at 110 ℃; for 1h; Inert atmosphere; Microwave irradiation;
DOI:10.1021/ol401197n

Reference yield: 50.0%

: 1440546-82-6
4-(benzyloxy)-2-((trimethylsilyl)ethynyl)aniline

: 1440546-83-7
4-(benzyloxy)-2-ethynylaniline

: 1440546-85-9
methyl 2-iodo-3,4-diisobutoxybenzoate

: 1440546-86-0
methyl 2-((2-amino-5-(benzyloxy)phenyl)ethynyl)-3,4-diisobutoxybenzoate

Guidance literature:: With bis(triphenylphosphine)palladium(II) dichloride;

Reference yield:

: 165190-62-5
4-(benzyloxy)-2-bromo-1-nitrobenzene

: 1440546-86-0
methyl 2-((2-amino-5-(benzyloxy)phenyl)ethynyl)-3,4-diisobutoxybenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tin(II) chloride dihdyrate / ethyl acetate / 50 °C / Inert atmosphere

2.1: triphenylphosphine; copper(l) iodide; triethylamine / toluene / 0.08 h / 20 °C / Inert atmosphere

2.2: 1 h / 110 °C / Inert atmosphere; Microwave irradiation

3.1: potassium carbonate / methanol / 0.5 h / 20 °C / Inert atmosphere

4.1: triphenylphosphine; copper(l) iodide; triethylamine / toluene / 0.08 h / 20 °C / Inert atmosphere

4.2: 1 h / 110 °C / Inert atmosphere; Microwave irradiation

With copper(l) iodide; tin(II) chloride dihdyrate; potassium carbonate; triethylamine; triphenylphosphine; In methanol; ethyl acetate; toluene;
DOI:10.1021/ol401197n