[(3R)-6-({4'-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2',6'-dimethylbiphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid

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Chemical Name:[(3R)-6-({4'-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2',6'-dimethylbiphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid
CAS No.:1373551-51-9
Molecular Formula:C₃₀H₃₂O₇S
Molecular Weight:536.646
Hs Code.:

Synonyms:[(3R)-6-({4'-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2',6'-dimethylbiphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid

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Chemical Property of [(3R)-6-({4'-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2',6'-dimethylbiphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid

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Technology Process of [(3R)-6-({4'-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2',6'-dimethylbiphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid

There total 8 articles about [(3R)-6-({4'-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2',6'-dimethylbiphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1373551-50-8
methyl [(3R)-6-({4'-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2',6'-dimethylbiphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetate

: 1373551-51-9
[(3R)-6-({4'-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2',6'-dimethylbiphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; methanol; at 50 ℃; for 2h;
DOI:10.1021/jm300170m

Reference yield:

: 29683-23-6
tetrahydrothiopyran-4-ol

: 1373551-51-9
[(3R)-6-({4'-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2',6'-dimethylbiphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / toluene / 20 h / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 1.5 h / -78 °C / Inert atmosphere

2.2: 16 h / -78 - 20 °C / Inert atmosphere

2.3: 2.5 h / 0 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,2-dimethoxyethane; water / 24 h / 95 °C / Inert atmosphere

4.1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 2 h / 0 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 0 °C

6.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / toluene / 20 h / 20 °C / Inert atmosphere

7.1: water; sodium hydroxide / tetrahydrofuran; methanol / 2 h / 50 °C

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; tributylphosphine; water; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; hexane; water; ethyl acetate; toluene; 1.1: Mitsunobu reaction / 3.1: Suzuki coupling / 6.1: Mitsunobu reaction;
DOI:10.1021/jm300170m

Reference yield:

: 922151-76-6
[2,6-dimethyl-4-(tetrahydro-2H-thiopyran-4-yloxy)phenyl]boronic acid

: 1373551-51-9
[(3R)-6-({4'-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2',6'-dimethylbiphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,2-dimethoxyethane; water / 24 h / 95 °C / Inert atmosphere

2: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 2 h / 0 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 0 °C

4: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / toluene / 20 h / 20 °C / Inert atmosphere

5: water; sodium hydroxide / tetrahydrofuran; methanol / 2 h / 50 °C

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tributylphosphine; water; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; ethyl acetate; toluene; 1: Suzuki coupling / 4: Mitsunobu reaction;
DOI:10.1021/jm300170m