methyl [(3R)-6-({4'-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2',6'-dimethylbiphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetate

Base Information

Chemical Name:methyl [(3R)-6-({4'-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2',6'-dimethylbiphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetate
CAS No.:1373551-50-8
Molecular Formula:C₃₁H₃₄O₇S
Molecular Weight:550.673
Hs Code.:

Synonyms:methyl [(3R)-6-({4'-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2',6'-dimethylbiphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetate

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Chemical Property of methyl [(3R)-6-({4'-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2',6'-dimethylbiphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetate

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Technology Process of methyl [(3R)-6-({4'-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2',6'-dimethylbiphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetate

There total 7 articles about methyl [(3R)-6-({4'-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2',6'-dimethylbiphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1234474-58-8
[(R)-6-hydroxy-2,3-dihydro-benzofuran-3-yl]-acetic acid methyl ester

: 922151-83-5
{4'-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2',6'-dimethylbiphenyl-3-yl}methanol

: 1373551-50-8
methyl [(3R)-6-({4'-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2',6'-dimethylbiphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetate

Guidance literature:: With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In toluene; at 20 ℃; for 20h; Inert atmosphere;
DOI:10.1021/jm300170m

Reference yield:

: 29683-23-6
tetrahydrothiopyran-4-ol

: 1373551-50-8
methyl [(3R)-6-({4'-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2',6'-dimethylbiphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / toluene / 20 h / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 1.5 h / -78 °C / Inert atmosphere

2.2: 16 h / -78 - 20 °C / Inert atmosphere

2.3: 2.5 h / 0 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,2-dimethoxyethane; water / 24 h / 95 °C / Inert atmosphere

4.1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 2 h / 0 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 0 °C

6.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / toluene / 20 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; tributylphosphine; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; water; ethyl acetate; toluene; 1.1: Mitsunobu reaction / 3.1: Suzuki coupling / 6.1: Mitsunobu reaction;
DOI:10.1021/jm300170m

Reference yield:

: 922151-76-6
[2,6-dimethyl-4-(tetrahydro-2H-thiopyran-4-yloxy)phenyl]boronic acid

: 1373551-50-8
methyl [(3R)-6-({4'-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-2',6'-dimethylbiphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,2-dimethoxyethane; water / 24 h / 95 °C / Inert atmosphere

2: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 2 h / 0 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 0 °C

4: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / toluene / 20 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tributylphosphine; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; 1,2-dimethoxyethane; water; ethyl acetate; toluene; 1: Suzuki coupling / 4: Mitsunobu reaction;
DOI:10.1021/jm300170m