Technology Process of 1-[3-(tert-butyl-diphenyl-silanyloxymethyl)-6-dimethoxymethyl-pyridin-2-yl]-ethylamine
There total 10 articles about 1-[3-(tert-butyl-diphenyl-silanyloxymethyl)-6-dimethoxymethyl-pyridin-2-yl]-ethylamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethanol;
DOI:10.1246/cl.2001.380
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 6M KOH / ethanol / 8 h / Heating
2: 7.73 mg / p-toluenesulfonic acid hydrate / Heating
3: 81 percent / DMAP / pyridine / 0.5 h / 0 °C
4: Pd(OAc)2; dppp; Et3N / toluene / 6 h / Heating
5: 1.28 g / 70 percent AcOH / tetrahydrofuran / 20 °C
6: 94 percent / CaCl2; NaBH4 / ethanol / 3.5 h / 0 - 20 °C
7: 86 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 0 - 20 °C
8: Et3N / CH2Cl2 / 0.17 h / 0 °C
9: 0.42 g / NaN3 / dimethylformamide / 0.5 h / 20 °C
10: H2 / 10 percent Pd-C / ethanol / 0.5 h / 20 °C
With
dmap; palladium diacetate; potassium hydroxide; sodium tetrahydroborate; sodium azide; 1,3-bis-(diphenylphosphino)propane; hydrogen; toluene-4-sulfonic acid; acetic acid; triethylamine; calcium chloride;
palladium on activated charcoal;
In
tetrahydrofuran; pyridine; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1246/bcsj.75.1583
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 7.73 mg / p-toluenesulfonic acid hydrate / Heating
2: 81 percent / DMAP / pyridine / 0.5 h / 0 °C
3: Pd(OAc)2; dppp; Et3N / toluene / 6 h / Heating
4: 1.28 g / 70 percent AcOH / tetrahydrofuran / 20 °C
5: 94 percent / CaCl2; NaBH4 / ethanol / 3.5 h / 0 - 20 °C
6: 86 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 0 - 20 °C
7: Et3N / CH2Cl2 / 0.17 h / 0 °C
8: 0.42 g / NaN3 / dimethylformamide / 0.5 h / 20 °C
9: H2 / 10 percent Pd-C / ethanol / 0.5 h / 20 °C
With
dmap; palladium diacetate; sodium tetrahydroborate; sodium azide; 1,3-bis-(diphenylphosphino)propane; hydrogen; toluene-4-sulfonic acid; acetic acid; triethylamine; calcium chloride;
palladium on activated charcoal;
In
tetrahydrofuran; pyridine; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1246/bcsj.75.1583
