1-[3-(tert-butyl-diphenyl-silanyloxymethyl)-6-dimethoxymethyl-pyridin-2-yl]-ethylamine

Base Information

Chemical Name:1-[3-(tert-butyl-diphenyl-silanyloxymethyl)-6-dimethoxymethyl-pyridin-2-yl]-ethylamine
CAS No.:348128-68-7
Molecular Formula:C₂₇H₃₆N₂O₃Si
Molecular Weight:464.68
Hs Code.:

1-[3-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-6-dimethoxymethyl-pyridin-2-yl]-ethylamine

Synonyms:1-[3-(tert-butyl-diphenyl-silanyloxymethyl)-6-dimethoxymethyl-pyridin-2-yl]-ethylamine

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Chemical Property of 1-[3-(tert-butyl-diphenyl-silanyloxymethyl)-6-dimethoxymethyl-pyridin-2-yl]-ethylamine

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Technology Process of 1-[3-(tert-butyl-diphenyl-silanyloxymethyl)-6-dimethoxymethyl-pyridin-2-yl]-ethylamine

There total 10 articles about 1-[3-(tert-butyl-diphenyl-silanyloxymethyl)-6-dimethoxymethyl-pyridin-2-yl]-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 348128-67-6
(RS)-2-(1-azidoethyl)-3-(t-butyldiphenylsiloxymethyl)-6-(dimethoxymethyl)pyridine

: 348128-68-7
1-[3-(tert-butyl-diphenyl-silanyloxymethyl)-6-dimethoxymethyl-pyridin-2-yl]-ethylamine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol;
DOI:10.1246/cl.2001.380

Reference yield:

: 156459-19-7
3-cyano-6-(dimethoxymethyl)-2-pyridone

: 348128-68-7
1-[3-(tert-butyl-diphenyl-silanyloxymethyl)-6-dimethoxymethyl-pyridin-2-yl]-ethylamine

Guidance literature:: Multi-step reaction with 10 steps

1: 6M KOH / ethanol / 8 h / Heating

2: 7.73 mg / p-toluenesulfonic acid hydrate / Heating

3: 81 percent / DMAP / pyridine / 0.5 h / 0 °C

4: Pd(OAc)2; dppp; Et₃N / toluene / 6 h / Heating

5: 1.28 g / 70 percent AcOH / tetrahydrofuran / 20 °C

6: 94 percent / CaCl₂; NaBH₄ / ethanol / 3.5 h / 0 - 20 °C

7: 86 percent / Et₃N; DMAP / CH₂Cl₂ / 2.5 h / 0 - 20 °C

8: Et₃N / CH₂Cl₂ / 0.17 h / 0 °C

9: 0.42 g / NaN₃ / dimethylformamide / 0.5 h / 20 °C

10: H₂ / 10 percent Pd-C / ethanol / 0.5 h / 20 °C

With dmap; palladium diacetate; potassium hydroxide; sodium tetrahydroborate; sodium azide; 1,3-bis-(diphenylphosphino)propane; hydrogen; toluene-4-sulfonic acid; acetic acid; triethylamine; calcium chloride; palladium on activated charcoal; In tetrahydrofuran; pyridine; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1246/bcsj.75.1583

Reference yield:

: 156459-20-0
6-(dimethoxymethyl)-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid

: 348128-68-7
1-[3-(tert-butyl-diphenyl-silanyloxymethyl)-6-dimethoxymethyl-pyridin-2-yl]-ethylamine

Guidance literature:: Multi-step reaction with 9 steps

1: 7.73 mg / p-toluenesulfonic acid hydrate / Heating

2: 81 percent / DMAP / pyridine / 0.5 h / 0 °C

3: Pd(OAc)2; dppp; Et₃N / toluene / 6 h / Heating

4: 1.28 g / 70 percent AcOH / tetrahydrofuran / 20 °C

5: 94 percent / CaCl₂; NaBH₄ / ethanol / 3.5 h / 0 - 20 °C

6: 86 percent / Et₃N; DMAP / CH₂Cl₂ / 2.5 h / 0 - 20 °C

7: Et₃N / CH₂Cl₂ / 0.17 h / 0 °C

8: 0.42 g / NaN₃ / dimethylformamide / 0.5 h / 20 °C

9: H₂ / 10 percent Pd-C / ethanol / 0.5 h / 20 °C

With dmap; palladium diacetate; sodium tetrahydroborate; sodium azide; 1,3-bis-(diphenylphosphino)propane; hydrogen; toluene-4-sulfonic acid; acetic acid; triethylamine; calcium chloride; palladium on activated charcoal; In tetrahydrofuran; pyridine; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1246/bcsj.75.1583