N₁-((5S,5aS,8aR,9R)-8-oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydro[1,3]dioxolo[4',5':4,5]benzo[f]isobenzofuran-5-yl)-4-((((2-bromoethyl)amino)carbonyl)amino)benzamide

Base Information

• Chemical Name: N₁-((5S,5aS,8aR,9R)-8-oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydro[1,3]dioxolo[4',5':4,5]benzo[f]isobenzofuran-5-yl)-4-((((2-bromoethyl)amino)carbonyl)amino)benzamide
• CAS No.: 1449741-72-3
• Molecular Formula: C₃₂H₃₂BrN₃O₉
• Molecular Weight: 682.525

Synonyms:N₁-((5S,5aS,8aR,9R)-8-oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydro[1,3]dioxolo[4',5':4,5]benzo[f]isobenzofuran-5-yl)-4-((((2-bromoethyl)amino)carbonyl)amino)benzamide

Chemical Property of N₁-((5S,5aS,8aR,9R)-8-oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydro[1,3]dioxolo[4',5':4,5]benzo[f]isobenzofuran-5-yl)-4-((((2-bromoethyl)amino)carbonyl)amino)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₁-((5S,5aS,8aR,9R)-8-oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydro[1,3]dioxolo[4',5':4,5]benzo[f]isobenzofuran-5-yl)-4-((((2-bromoethyl)amino)carbonyl)amino)benzamide

There total 4 articles about N₁-((5S,5aS,8aR,9R)-8-oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydro[1,3]dioxolo[4',5':4,5]benzo[f]isobenzofuran-5-yl)-4-((((2-bromoethyl)amino)carbonyl)amino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N1-((5S,5aS,8aR,9R)-8-oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydro[1,3]dioxolo[4',5':4,5]benzo[f]isobenzofuran-5-yl)-4-aminobenzamide (1365699-34-8) + 2-bromoethyl isocyanate (42865-19-0) → N1-((5S,5aS,8aR,9R)-8-oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydro[1,3]dioxolo[4',5':4,5]benzo[f]isobenzofuran-5-yl)-4-((((2-bromoethyl)amino)carbonyl)amino)benzamide (1449741-72-3)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 1h;

DOI:10.1016/j.bmc.2013.06.033

Reference yield:

4-nitro-benzoyl chloride (122-04-3) → N1-((5S,5aS,8aR,9R)-8-oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydro[1,3]dioxolo[4',5':4,5]benzo[f]isobenzofuran-5-yl)-4-((((2-bromoethyl)amino)carbonyl)amino)benzamide (1449741-72-3)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

2: hydrogen; palladium 10% on activated carbon / ethyl acetate / 12 h / 20 °C

3: dichloromethane / 1 h / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; In dichloromethane; ethyl acetate;

DOI:10.1016/j.bmc.2013.06.033

Reference yield:

N1-((5S,5aS,8aR,9R)-8-oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydro[1,3]dioxolo[4',5':4,5]benzo[f]isobenzofuran-5-yl)-4-nitrobenzamide (1365699-32-6) → N1-((5S,5aS,8aR,9R)-8-oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydro[1,3]dioxolo[4',5':4,5]benzo[f]isobenzofuran-5-yl)-4-((((2-bromoethyl)amino)carbonyl)amino)benzamide (1449741-72-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 12 h / 20 °C

2: dichloromethane / 1 h / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; In dichloromethane; ethyl acetate;

DOI:10.1016/j.bmc.2013.06.033

upstream raw materials:

N₁-((5S,5aS,8aR,9R)-8-oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydro[1,3]dioxolo[4',5':4,5]benzo[f]isobenzofuran-5-yl)-4-aminobenzamide

2-bromoethyl isocyanate

4β-amino-4-deoxypodophyllotoxin

4-nitro-benzoyl chloride

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1449741-72-3 N₁-((5S,5aS,8aR,9R)-8-oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydro[1,3]dioxolo[4',5':4,5]benzo[f]isobenzofuran-5-yl)-4-((((2-bromoethyl)amino)carbonyl)amino)benzamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send