dibutyl 4-O-tert-butyldimethylsilyl-3,6-di-O-benzyl-2-O-pivaloyl-β-D-glucopyranoside phosphate

Base Information

• Chemical Name: dibutyl 4-O-tert-butyldimethylsilyl-3,6-di-O-benzyl-2-O-pivaloyl-β-D-glucopyranoside phosphate
• CAS No.: 253683-26-0
• Molecular Formula: C₃₉H₆₃O₁₀PSi
• Molecular Weight: 750.982

Synonyms:dibutyl 4-O-tert-butyldimethylsilyl-3,6-di-O-benzyl-2-O-pivaloyl-β-D-glucopyranoside phosphate

Chemical Property of dibutyl 4-O-tert-butyldimethylsilyl-3,6-di-O-benzyl-2-O-pivaloyl-β-D-glucopyranoside phosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dibutyl 4-O-tert-butyldimethylsilyl-3,6-di-O-benzyl-2-O-pivaloyl-β-D-glucopyranoside phosphate

There total 8 articles about dibutyl 4-O-tert-butyldimethylsilyl-3,6-di-O-benzyl-2-O-pivaloyl-β-D-glucopyranoside phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

Phosphoric acid (2S,3R,4R,5R,6R)-4-benzyloxy-6-benzyloxymethyl-5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-tetrahydro-pyran-2-yl ester dibutyl ester + pivaloyl chloride (3282-30-2) → dibutyl 4-O-tert-butyldimethylsilyl-3,6-di-O-benzyl-2-O-pivaloyl-β-D-glucopyranoside phosphate (253683-26-0)

Guidance literature:

With dmap; In dichloromethane; at 0 - 20 ℃; for 1h;

DOI:10.1021/ja016227r

Reference yield: 78.0%

pivaloyl chloride (3282-30-2) + dibutyl phosphate (107-66-4) + 1,5-anhydro-4-O-tert-butyldimethylsilyl-2-deoxy-3,6-di-O-benzyl-D-arabino-hex-1-enitol (253683-41-9) → dibutyl 4-O-tert-butyldimethylsilyl-3,6-di-O-benzyl-2-O-pivaloyl-β-D-glucopyranoside phosphate (253683-26-0)

Guidance literature:

1,5-anhydro-4-O-tert-butyldimethylsilyl-2-deoxy-3,6-di-O-benzyl-D-arabino-hex-1-enitol; With 3,3-dimethyldioxirane; In dichloromethane; acetone; at 0 ℃; for 0.333333h;

dibutyl phosphate; In dichloromethane; at -78 ℃; for 0.25h;

pivaloyl chloride; With dmap; In dichloromethane; at 20 ℃; for 2h; Further stages.;

DOI:10.1021/jo015987h

Reference yield:

Phosphoric acid (3R,4R,5R,6R)-4-benzyloxy-6-benzyloxymethyl-5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-tetrahydro-pyran-2-yl ester dibutyl ester + pivaloyl chloride (3282-30-2) → dibutyl 4-O-tert-butyldimethylsilyl-3,6-di-O-benzyl-2-O-pivaloyl-α-D-glucopyranoside phosphate + dibutyl 4-O-tert-butyldimethylsilyl-3,6-di-O-benzyl-2-O-pivaloyl-β-D-glucopyranoside phosphate (253683-26-0)

Guidance literature:

With dmap; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

DOI:10.1021/ja016227r

upstream raw materials:

pivaloyl chloride

dibutyl phosphate

1,5-anhydro-4-O-tert-butyldimethylsilyl-2-deoxy-3,6-di-O-benzyl-D-arabino-hex-1-enitol

((1S,3R,4R,5R,6R)-5-Benzyloxy-3-benzyloxymethyl-2,7-dioxa-bicyclo[4.1.0]hept-4-yloxy)-tert-butyl-dimethyl-silane

Downstream raw materials:

n-pentenyl 4-O-tert-butyldimethylsilyl-3,6-di-O-benzyl-2-O-pivaloyl-β-D-glucopyranoside

3,6-di-O-benzyl-2-O-pivaloyl-β-D-glucopyranosyl-(1->6)-1,2:3,4-di-O-isopropylidene-α-D-galactopyranoside

n-pentenyl 4,6-di-O-benzyl-3-O-levulinyl-2-O-pivaloyl-β-D-galactopyranosyl-(1->4)-3,6-di-O-benzyl-2-O-pivaloyl-β-D-glucopyranoside

n-pentenyl 4,6-di-O-benzyl-2-O-pivaloyl-β-D-galactopyranosyl-(1->4)-3,6-di-O-benzyl-2-O-pivaloyl-β-D-glucopyranoside

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 253683-26-0 dibutyl 4-O-tert-butyldimethylsilyl-3,6-di-O-benzyl-2-O-pivaloyl-β-D-glucopyranoside phosphate

Send

Send

Metric Ton KG G Pound L ML

Send

Send