tert-butyl 2-{(1S)-1-[({(1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-oxopropyl}amino)carbonyl]-2,2-dimethylpropyl}amino-2-oxoethyl(cyclopropyl) carbamate

Base Information

• Chemical Name: tert-butyl 2-{(1S)-1-[({(1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-oxopropyl}amino)carbonyl]-2,2-dimethylpropyl}amino-2-oxoethyl(cyclopropyl) carbamate
• CAS No.: 565227-89-6
• Molecular Formula: C₃₇H₅₂N₄O₉S
• Molecular Weight: 728.907

Synonyms:tert-butyl 2-{(1S)-1-[({(1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-oxopropyl}amino)carbonyl]-2,2-dimethylpropyl}amino-2-oxoethyl(cyclopropyl) carbamate

Chemical Property of tert-butyl 2-{(1S)-1-[({(1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-oxopropyl}amino)carbonyl]-2,2-dimethylpropyl}amino-2-oxoethyl(cyclopropyl) carbamate

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Technology Process of tert-butyl 2-{(1S)-1-[({(1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-oxopropyl}amino)carbonyl]-2,2-dimethylpropyl}amino-2-oxoethyl(cyclopropyl) carbamate

There total 3 articles about tert-butyl 2-{(1S)-1-[({(1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-oxopropyl}amino)carbonyl]-2,2-dimethylpropyl}amino-2-oxoethyl(cyclopropyl) carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

tert-butyl 2-{(1S)-1-[({(1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-hydroxypropyl}amino)carbonyl]-2,2-dimethylpropyl}amino-2-oxoethyl(cyclopropyl) carbamate (565227-88-5) → tert-butyl 2-{(1S)-1-[({(1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-oxopropyl}amino)carbonyl]-2,2-dimethylpropyl}amino-2-oxoethyl(cyclopropyl) carbamate (565227-89-6)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 - 20 ℃;

DOI:10.1002/jlcr.676

Reference yield:

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile (58632-95-4) → tert-butyl 2-{(1S)-1-[({(1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-oxopropyl}amino)carbonyl]-2,2-dimethylpropyl}amino-2-oxoethyl(cyclopropyl) carbamate (565227-89-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / triethylamine / H₂O; dioxane / 4 h / 20 °C

2: 90 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / -78 - 20 °C

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In 1,4-dioxane; dichloromethane; water; 2: Swern oxidation;

DOI:10.1002/jlcr.676

Reference yield:

DMP 853 (183812-77-3) → tert-butyl 2-{(1S)-1-[({(1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-oxopropyl}amino)carbonyl]-2,2-dimethylpropyl}amino-2-oxoethyl(cyclopropyl) carbamate (565227-89-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / triethylamine / H₂O; dioxane / 4 h / 20 °C

2: 90 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / -78 - 20 °C

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In 1,4-dioxane; dichloromethane; water; 2: Swern oxidation;

DOI:10.1002/jlcr.676

upstream raw materials:

tert-butyl 2-{(1S)-1-[({(1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-hydroxypropyl}amino)carbonyl]-2,2-dimethylpropyl}amino-2-oxoethyl(cyclopropyl) carbamate

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

DMP 853

Downstream raw materials:

tert-butyl 2-{(1S)-1-[({(1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-hydroxypropyl}amino)carbonyl]-2,2-dimethylpropyl}amino-2-oxoethyl(cyclopropyl) carbamate

tert-butyl 2-{(1S)-1-[({(1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-hydroxy-2-[3H]-propyl}amino)carbonyl]-2,2-dimethylpropyl}amino-2-oxoethyl(cyclopropyl) carbamate

DMP 853

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