4-ETHOXYPHENYLACETONITRILE

Base Information

• Chemical Name: 4-ETHOXYPHENYLACETONITRILE
• CAS No.: 6775-77-5
• Molecular Formula: C10H11NO
• Molecular Weight: 161.203
• Hs Code.: 2926909090
• Mol file: 6775-77-5.mol

Synonyms:Acetonitrile,(p-ethoxyphenyl)- (6CI,7CI,8CI);(p-Ethoxyphenyl)acetonitrile;4-Ethoxyphenylacetonitrile;p-Ethoxybenzeneacetonitrile;p-Ethoxybenzyl cyanide;Benzeneacetonitrile, 4-ethoxy-;

Chemical Property of 4-ETHOXYPHENYLACETONITRILE

Chemical Property:

• Vapor Pressure: 0.00337mmHg at 25°C
• Melting Point: 44 °C
• Refractive Index: 1.514
• Boiling Point: 282.4 °C at 760 mmHg
• Flash Point: 118.7 °C
• PSA: 33.02000
• Density: 1.032 g/cm³
• LogP: 2.15138

Purity/Quality:

97% ^*data from raw suppliers

4-Ethoxyphenylacetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-ETHOXYPHENYLACETONITRILE

There total 7 articles about 4-ETHOXYPHENYLACETONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-cyanomethylphenol (14191-95-8) → 4-ethoxyphenylacetonitrile (6775-77-5)

Guidance literature:

With potassium carbonate; In acetone; for 8h; Heating;

DOI:10.1021/ja00323a048

Reference yield:

4-ethoxybenzyl alcohol (6214-44-4) → 4-ethoxyphenylacetonitrile (6775-77-5)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / dioxane / 20 °C

2: acetonitrile / 20 °C

With thionyl chloride; In 1,4-dioxane; acetonitrile;

DOI:10.1016/S0960-894X(01)00403-6

Reference yield:

4-ethoxybenzaldehyde (10031-82-0) → 4-ethoxyphenylacetonitrile (6775-77-5)

Guidance literature:

Multi-step reaction with 3 steps

1: NaBH₄ / methanol / 20 °C

2: SOCl₂ / dioxane / 20 °C

3: acetonitrile / 20 °C

With sodium tetrahydroborate; thionyl chloride; In 1,4-dioxane; methanol; acetonitrile;

DOI:10.1016/S0960-894X(01)00403-6

upstream raw materials:

4-cyanomethylphenol

ethyl iodide

tetraethylammoniumcyanide

4-ethoxybenzylchloride

Downstream raw materials:

4'-ethoxy-2,4,6-trihydroxy-deoxybenzoin

(4-ethoxy-phenethyl)-dimethyl-amine

1-(4-ethoxy-phenyl)-cyclopentanecarbonitrile

4-ethoxyphenylacetic acid