methyl (2'-chloro-6-((trimethylsilyl)oxy)-1,2,3,4-tetrahydro-[1,1'-biphenyl]-1-yl)carbamate

Base Information

Chemical Name:methyl (2'-chloro-6-((trimethylsilyl)oxy)-1,2,3,4-tetrahydro-[1,1'-biphenyl]-1-yl)carbamate
CAS No.:103933-03-5
Molecular Formula:C₁₇H₂₄ClNO₃Si
Molecular Weight:353.921
Hs Code.:

Synonyms:methyl (2'-chloro-6-((trimethylsilyl)oxy)-1,2,3,4-tetrahydro-[1,1'-biphenyl]-1-yl)carbamate

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Chemical Property of methyl (2'-chloro-6-((trimethylsilyl)oxy)-1,2,3,4-tetrahydro-[1,1'-biphenyl]-1-yl)carbamate

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Technology Process of methyl (2'-chloro-6-((trimethylsilyl)oxy)-1,2,3,4-tetrahydro-[1,1'-biphenyl]-1-yl)carbamate

There total 3 articles about methyl (2'-chloro-6-((trimethylsilyl)oxy)-1,2,3,4-tetrahydro-[1,1'-biphenyl]-1-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 75-77-4
chloro-trimethyl-silane

: 103904-69-4
2-(o-chlorophenyl)-2-<(methoxycarbonyl)amino>cyclohexanone

: 103933-03-5
methyl (2'-chloro-6-((trimethylsilyl)oxy)-1,2,3,4-tetrahydro-[1,1'-biphenyl]-1-yl)carbamate

Guidance literature:: 2-(o-chlorophenyl)-2-<(methoxycarbonyl)amino>cyclohexanone; With n-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 2h;

chloro-trimethyl-silane; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 3.08333h;

Reference yield:

: 35211-10-0,83777-65-5
norketamine

: 103933-03-5
methyl (2'-chloro-6-((trimethylsilyl)oxy)-1,2,3,4-tetrahydro-[1,1'-biphenyl]-1-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / Na₂CO₃ / benzene / 3 h / Heating

2: 1.) lithium diisopropylamide / 1.) THF, hexane, -78 deg C, 2 h, 2.) THF, hexane, a) from -78 deg C to RT, 20 min, b) RT, 45 min

With sodium carbonate; lithium diisopropyl amide; In benzene;
DOI:10.1021/jm00161a043

Reference yield:

: 79499-57-3
(±)-1-((2-chlorophenyl)(imino)methyl)cyclopentan-1-ol

: 103933-03-5
methyl (2'-chloro-6-((trimethylsilyl)oxy)-1,2,3,4-tetrahydro-[1,1'-biphenyl]-1-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / isopropyl alcohol

1.2: 0.12 h / 180 - 200 °C

2.1: sodium carbonate / benzene / 3 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C

3.2: 3.08 h / -78 - 20 °C

With hydrogenchloride; n-butyllithium; sodium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; isopropyl alcohol; benzene;