3-[4-(chloromethyl)phenyl]-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazole

Base Information

Chemical Name:3-[4-(chloromethyl)phenyl]-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazole
CAS No.:930110-17-1
Molecular Formula:C₁₇H₁₁Cl₃F₃NO
Molecular Weight:408.635
Hs Code.:

Synonyms:3-[4-(chloromethyl)phenyl]-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazole

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Chemical Property of 3-[4-(chloromethyl)phenyl]-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazole

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Technology Process of 3-[4-(chloromethyl)phenyl]-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazole

There total 4 articles about 3-[4-(chloromethyl)phenyl]-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67492-50-6
(3,5-dichlorophenyl)boronic acid

: 930110-17-1
3-[4-(chloromethyl)phenyl]-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; water / 3 h / Heating / reflux

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.67 h / 40 °C

2.2: 18 h / 20 °C

3.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 3 h / 50 °C

3.2: pH 3

4.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 3 h / Heating / reflux

With sodium tetrahydroborate; N-chloro-succinimide; thionyl chloride; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 864736-12-9
5-(3,5-dichlorophenyl)-3-[4-(hydroxymethyl)phenyl]-5-trifluoromethyl-4,5-dihydro-isoxazole

: 930110-17-1
3-[4-(chloromethyl)phenyl]-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazole

Guidance literature:: 5-(3,5-dichlorophenyl)-3-[4-(hydroxymethyl)phenyl]-5-trifluoromethyl-4,5-dihydro-isoxazole; With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; for 3h; Heating / reflux;

With water; sodium hydrogencarbonate; In dichloromethane;

Reference yield:

: 864725-22-4
1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

: 930110-17-1
3-[4-(chloromethyl)phenyl]-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.67 h / 40 °C

1.2: 18 h / 20 °C

2.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 3 h / 50 °C

2.2: pH 3

3.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 3 h / Heating / reflux

With sodium tetrahydroborate; N-chloro-succinimide; thionyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;