5-(3,5-dichlorophenyl)-3-[4-(hydroxymethyl)phenyl]-5-trifluoromethyl-4,5-dihydro-isoxazole

Base Information

Chemical Name:5-(3,5-dichlorophenyl)-3-[4-(hydroxymethyl)phenyl]-5-trifluoromethyl-4,5-dihydro-isoxazole
CAS No.:864736-12-9
Molecular Formula:C₁₇H₁₂Cl₂F₃NO₂
Molecular Weight:390.189
Hs Code.:

Synonyms:5-(3,5-dichlorophenyl)-3-[4-(hydroxymethyl)phenyl]-5-trifluoromethyl-4,5-dihydro-isoxazole

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Chemical Property of 5-(3,5-dichlorophenyl)-3-[4-(hydroxymethyl)phenyl]-5-trifluoromethyl-4,5-dihydro-isoxazole

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Technology Process of 5-(3,5-dichlorophenyl)-3-[4-(hydroxymethyl)phenyl]-5-trifluoromethyl-4,5-dihydro-isoxazole

There total 3 articles about 5-(3,5-dichlorophenyl)-3-[4-(hydroxymethyl)phenyl]-5-trifluoromethyl-4,5-dihydro-isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67492-50-6
(3,5-dichlorophenyl)boronic acid

: 864736-12-9
5-(3,5-dichlorophenyl)-3-[4-(hydroxymethyl)phenyl]-5-trifluoromethyl-4,5-dihydro-isoxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; water / 3 h / Heating / reflux

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.67 h / 40 °C

2.2: 18 h / 20 °C

3.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 3 h / 50 °C

3.2: pH 3

With sodium tetrahydroborate; N-chloro-succinimide; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] benzoic acid methyl ester

: 864736-12-9
5-(3,5-dichlorophenyl)-3-[4-(hydroxymethyl)phenyl]-5-trifluoromethyl-4,5-dihydro-isoxazole

Guidance literature:: 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] benzoic acid methyl ester; With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 50 ℃; for 3h;

With hydrogenchloride; water; In tetrahydrofuran; methanol; pH=3;

Reference yield:

: 864725-22-4
1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

: 864736-12-9
5-(3,5-dichlorophenyl)-3-[4-(hydroxymethyl)phenyl]-5-trifluoromethyl-4,5-dihydro-isoxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.67 h / 40 °C

1.2: 18 h / 20 °C

2.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 3 h / 50 °C

2.2: pH 3

With sodium tetrahydroborate; N-chloro-succinimide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;