Methanesulfonic acid 3-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-bis-(3-methanesulfonyloxy-propoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-propyl ester

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Chemical Name:Methanesulfonic acid 3-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-bis-(3-methanesulfonyloxy-propoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-propyl ester
CAS No.:203795-64-6
Molecular Formula:C₅₅H₈₀O₁₃S₃
Molecular Weight:1045.43
Hs Code.:

Methanesulfonic acid 3-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-bis-(3-methanesulfonyloxy-propoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-propyl ester

Synonyms:Methanesulfonic acid 3-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-bis-(3-methanesulfonyloxy-propoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-propyl ester

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Chemical Property of Methanesulfonic acid 3-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-bis-(3-methanesulfonyloxy-propoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-propyl ester

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Technology Process of Methanesulfonic acid 3-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-bis-(3-methanesulfonyloxy-propoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-propyl ester

There total 5 articles about Methanesulfonic acid 3-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-bis-(3-methanesulfonyloxy-propoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 124-63-0
methanesulfonyl chloride

: 203795-58-8
3-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-Bis-(3-hydroxy-propoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-propan-1-ol

: 203795-64-6
Methanesulfonic acid 3-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-bis-(3-methanesulfonyloxy-propoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-propyl ester

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1021/ja973881r

Reference yield:

: 3758-71-2
3α,7α,12α-trihydroxycholan-24-ol

: 203795-64-6
Methanesulfonic acid 3-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-bis-(3-methanesulfonyloxy-propoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-propyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / Et₃N / dimethylformamide

2: 96 percent / NaH / tetrahydrofuran

3: 1.) 9-BBN, 2.) H₂O₂, NaOH / 1.) THF

4: 99 percent / Et₃N / CH₂Cl₂

With sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; dihydrogen peroxide; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja973881r

Reference yield:

: 1448-36-8
methyl cholate

: 203795-64-6
Methanesulfonic acid 3-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-bis-(3-methanesulfonyloxy-propoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-propyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / LiAlH₄ / tetrahydrofuran

2: 90 percent / Et₃N / dimethylformamide

3: 96 percent / NaH / tetrahydrofuran

4: 1.) 9-BBN, 2.) H₂O₂, NaOH / 1.) THF

5: 99 percent / Et₃N / CH₂Cl₂

With sodium hydroxide; lithium aluminium tetrahydride; 9-borabicyclo[3.3.1]nonane dimer; dihydrogen peroxide; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja973881r