6-amino-1'-benzyl-5-cyano-3-methyl-2'-oxo-1-phenyl-1,1',3',4-tetrahydrospiro(pyrano[2,3-c]pyrazole-4,3'-[2'H]-indole)

Base Information

• Chemical Name: 6-amino-1'-benzyl-5-cyano-3-methyl-2'-oxo-1-phenyl-1,1',3',4-tetrahydrospiro(pyrano[2,3-c]pyrazole-4,3'-[2'H]-indole)
• CAS No.: 445390-57-8
• Molecular Formula: C₂₈H₂₁N₅O₂
• Molecular Weight: 459.507
• Mol file: 445390-57-8.mol

Synonyms:6'?amino?3'?methyl?2?oxo-1'?phenyl?1'H?spiro[1?benzylindoline?3,4'?pyrano[2,3?c]pyrazole]?5'?carbonitrile

Chemical Property of 6-amino-1'-benzyl-5-cyano-3-methyl-2'-oxo-1-phenyl-1,1',3',4-tetrahydrospiro(pyrano[2,3-c]pyrazole-4,3'-[2'H]-indole)

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-amino-1'-benzyl-5-cyano-3-methyl-2'-oxo-1-phenyl-1,1',3',4-tetrahydrospiro(pyrano[2,3-c]pyrazole-4,3'-[2'H]-indole)

There total 3 articles about 6-amino-1'-benzyl-5-cyano-3-methyl-2'-oxo-1-phenyl-1,1',3',4-tetrahydrospiro(pyrano[2,3-c]pyrazole-4,3'-[2'H]-indole) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-benzylisatin (1217-89-6) + 3-methyl-1-phenyl-1,5-dihydro-4H-pyrazol-4-one (56694-49-6) + malononitrile (109-77-3) → 6'?amino?3'?methyl?2?oxo-1'?phenyl?1'H?spiro[1?benzylindoline?3,4'?pyrano[2,3?c]pyrazole]?5'?carbonitrile (445390-57-8)

Guidance literature:

With cesium fluoride; In ethanol; at 20 ℃; for 0.116667h;

DOI:10.1002/jhet.3846

Reference yield: 97.0%

1-benzylisatin (1217-89-6) + edaravone (89-25-8) + malononitrile (109-77-3) → 6'?amino?3'?methyl?2?oxo-1'?phenyl?1'H?spiro[1?benzylindoline?3,4'?pyrano[2,3?c]pyrazole]?5'?carbonitrile (445390-57-8)

Guidance literature:

With ammonium cerium (IV) nitrate; In water; at 20 ℃; for 0.133333h; Sonication; Green chemistry;

DOI:10.1007/s00044-013-0671-8

Reference yield: 80.0%

1-benzylisatin (1217-89-6) + ethyl acetoacetate (141-97-9) + phenylhydrazine (100-63-0) + malononitrile (109-77-3) → 6'?amino?3'?methyl?2?oxo-1'?phenyl?1'H?spiro[1?benzylindoline?3,4'?pyrano[2,3?c]pyrazole]?5'?carbonitrile (445390-57-8)

Guidance literature:

ethyl acetoacetate; phenylhydrazine; With polyaniline/Fe₃O₄/carbon nanotube; In water; at 20 ℃; for 0.166667h;

1-benzylisatin; malononitrile; In water; at 20 ℃; for 0.75h;

DOI:10.1007/s11164-017-3228-5

upstream raw materials:

1-benzylisatin

edaravone

malononitrile

ethyl acetoacetate