(1'S,2R,3R,5S)-3-Diphenylphosphinoyl-2-(4-methoxyphenyl)-5-[phenyl(4-methoxybenzoyloxy)methyl]-2-trimethylsilyloxytetrahydrofuran

Base Information

Chemical Name:(1'S,2R,3R,5S)-3-Diphenylphosphinoyl-2-(4-methoxyphenyl)-5-[phenyl(4-methoxybenzoyloxy)methyl]-2-trimethylsilyloxytetrahydrofuran
CAS No.:335274-37-8
Molecular Formula:C₄₁H₄₃O₇PSi
Molecular Weight:706.847
Hs Code.:

Synonyms:(1'S,2R,3R,5S)-3-Diphenylphosphinoyl-2-(4-methoxyphenyl)-5-[phenyl(4-methoxybenzoyloxy)methyl]-2-trimethylsilyloxytetrahydrofuran

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1'S,2R,3R,5S)-3-Diphenylphosphinoyl-2-(4-methoxyphenyl)-5-[phenyl(4-methoxybenzoyloxy)methyl]-2-trimethylsilyloxytetrahydrofuran

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Technology Process of (1'S,2R,3R,5S)-3-Diphenylphosphinoyl-2-(4-methoxyphenyl)-5-[phenyl(4-methoxybenzoyloxy)methyl]-2-trimethylsilyloxytetrahydrofuran

There total 3 articles about (1'S,2R,3R,5S)-3-Diphenylphosphinoyl-2-(4-methoxyphenyl)-5-[phenyl(4-methoxybenzoyloxy)methyl]-2-trimethylsilyloxytetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 75-77-4
chloro-trimethyl-silane

: 335274-31-2
(1S,2S)-1,2-Bis(4-methoxybenzoyloxy)-4-diphenylphosphinoyl-1-phenylbutane

: 335274-37-8
(1'S,2R,3R,5S)-3-Diphenylphosphinoyl-2-(4-methoxyphenyl)-5-[phenyl(4-methoxybenzoyloxy)methyl]-2-trimethylsilyloxytetrahydrofuran

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 48h;
DOI:10.1039/b008500f

Reference yield:

: 100-07-2
4-methoxy-benzoyl chloride

: 335274-37-8
(1'S,2R,3R,5S)-3-Diphenylphosphinoyl-2-(4-methoxyphenyl)-5-[phenyl(4-methoxybenzoyloxy)methyl]-2-trimethylsilyloxytetrahydrofuran

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / Et₃N; DMAP / CH₂Cl₂ / 18 h / 20 °C

2: 89 percent / LDA / tetrahydrofuran; hexane / 48 h / -78 °C

With dmap; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1039/b008500f

Reference yield:

: 230965-19-2
(1S,2S)-4-Diphenylphosphinoyl-1-phenylbutane-1,2-diol

: 335274-37-8
(1'S,2R,3R,5S)-3-Diphenylphosphinoyl-2-(4-methoxyphenyl)-5-[phenyl(4-methoxybenzoyloxy)methyl]-2-trimethylsilyloxytetrahydrofuran

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / Et₃N; DMAP / CH₂Cl₂ / 18 h / 20 °C

2: 89 percent / LDA / tetrahydrofuran; hexane / 48 h / -78 °C

With dmap; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1039/b008500f