N,2-dimethyl-3-((4-(4-((4-(trifluoromethoxy)benzyl)oxy)piperidin-1-yl)-1,3,5-triazin-2-yl)amino)benzamide

Base Information

Chemical Name:N,2-dimethyl-3-((4-(4-((4-(trifluoromethoxy)benzyl)oxy)piperidin-1-yl)-1,3,5-triazin-2-yl)amino)benzamide
CAS No.:1332302-38-1
Molecular Formula:C₂₅H₂₇F₃N₆O₃
Molecular Weight:516.523
Hs Code.:

Synonyms:N,2-dimethyl-3-((4-(4-((4-(trifluoromethoxy)benzyl)oxy)piperidin-1-yl)-1,3,5-triazin-2-yl)amino)benzamide

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Chemical Property of N,2-dimethyl-3-((4-(4-((4-(trifluoromethoxy)benzyl)oxy)piperidin-1-yl)-1,3,5-triazin-2-yl)amino)benzamide

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Technology Process of N,2-dimethyl-3-((4-(4-((4-(trifluoromethoxy)benzyl)oxy)piperidin-1-yl)-1,3,5-triazin-2-yl)amino)benzamide

There total 5 articles about N,2-dimethyl-3-((4-(4-((4-(trifluoromethoxy)benzyl)oxy)piperidin-1-yl)-1,3,5-triazin-2-yl)amino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 926254-13-9
3-amino-N,2-dimethylbenzamide

: 1332302-39-2
2-chloro-4-(4-((4-(trifluoromethoxy)benzyl)oxy)piperidin-1-yl)-1,3,5-triazine

: 1332302-38-1
N,2-dimethyl-3-((4-(4-((4-(trifluoromethoxy)benzyl)oxy)piperidin-1-yl)-1,3,5-triazin-2-yl)amino)benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 80 ℃; for 24h;

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1332302-38-1
N,2-dimethyl-3-((4-(4-((4-(trifluoromethoxy)benzyl)oxy)piperidin-1-yl)-1,3,5-triazin-2-yl)amino)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C / Cooling with ice

1.2: 15 h / 20 °C / Cooling with ice

2.1: dichloromethane / 2 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 80 °C

4.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 24 h / 80 °C

With sodium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;

Reference yield:

: 50824-05-0
4-trifluoromethoxybenzyl bromide

: 1332302-38-1
N,2-dimethyl-3-((4-(4-((4-(trifluoromethoxy)benzyl)oxy)piperidin-1-yl)-1,3,5-triazin-2-yl)amino)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C / Cooling with ice

1.2: 15 h / 20 °C / Cooling with ice

2.1: dichloromethane / 2 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 80 °C

4.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 24 h / 80 °C

With sodium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;