tert-butyl 4-(5-cyano-4-((2,5-difluorophenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(5-cyano-4-((2,5-difluorophenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate
• CAS No.: 1258001-66-9
• Molecular Formula: C₂₁H₂₄F₂N₄O₃
• Molecular Weight: 418.443
• Mol file: 1258001-66-9.mol

Synonyms:tert-butyl 4-(5-cyano-4-((2,5-difluorophenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

Chemical Property of tert-butyl 4-(5-cyano-4-((2,5-difluorophenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-(5-cyano-4-((2,5-difluorophenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

There total 8 articles about tert-butyl 4-(5-cyano-4-((2,5-difluorophenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-difluorophenol (2713-31-7) + tert-butyl 4-(5-cyano-4-((methylsulfonyloxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate (1258001-25-0) → tert-butyl 4-(5-cyano-4-((2,5-difluorophenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate (1258001-66-9)

Guidance literature:

With caesium carbonate; In acetonitrile; for 15h; Reflux;

Reference yield:

tert-butyl 4-(5-bromo-4-ethoxycarbonylpyrazol-1-yl)piperidine-1-carboxylate (1258001-22-7) → tert-butyl 4-(5-cyano-4-((2,5-difluorophenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate (1258001-66-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 15 h / 0 - 20 °C / Reflux

1.2: 0.33 h / 20 °C / Cooling with ice

2.1: N,N-dimethyl-formamide / 4 h / 165 °C

3.1: triethylamine / dichloromethane / 4.5 h / 20 °C

4.1: caesium carbonate / acetonitrile / 15 h / Reflux

With dimethylsulfide borane complex; caesium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → tert-butyl 4-(5-cyano-4-((2,5-difluorophenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate (1258001-66-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 19 h / 0 - 20 °C

2.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 2.75 h / -78 - -10 °C

2.2: 20 h / -10 - 20 °C

3.1: triethylamine / dichloromethane / 4.5 h / 20 °C

4.1: caesium carbonate / acetonitrile / 15 h / Reflux

With diisobutylaluminium hydride; caesium carbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;

upstream raw materials:

2,5-difluorophenol

tert-butyl 4-(5-cyano-4-((methylsulfonyloxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

t-butyl 4-hydroxy piperidine-1-carboxylate

tert-butyl 4-(5-amino-4-(ethoxycarbonyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

Downstream raw materials:

4-((2,5-difluorophenoxy)methyl)-1-(piperidin-4-yl)-1H-pyrazole-5-carbonitrile

1-methylcyclopropyl 4-{5-cyano-4-[(2,5-difluorophenoxy)methyl]-1H-pyrazol-1-yl}piperidine-1-carboxylate