4-((2,5-difluorophenoxy)methyl)-1-(piperidin-4-yl)-1H-pyrazole-5-carbonitrile

Base Information

Chemical Name:4-((2,5-difluorophenoxy)methyl)-1-(piperidin-4-yl)-1H-pyrazole-5-carbonitrile
CAS No.:1258001-67-0
Molecular Formula:C₁₆H₁₆F₂N₄O
Molecular Weight:318.326
Hs Code.:

Synonyms:4-((2,5-difluorophenoxy)methyl)-1-(piperidin-4-yl)-1H-pyrazole-5-carbonitrile

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Chemical Property of 4-((2,5-difluorophenoxy)methyl)-1-(piperidin-4-yl)-1H-pyrazole-5-carbonitrile

Chemical Property:

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Technology Process of 4-((2,5-difluorophenoxy)methyl)-1-(piperidin-4-yl)-1H-pyrazole-5-carbonitrile

There total 9 articles about 4-((2,5-difluorophenoxy)methyl)-1-(piperidin-4-yl)-1H-pyrazole-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1258001-66-9
tert-butyl 4-(5-cyano-4-((2,5-difluorophenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

: 1258001-67-0
4-((2,5-difluorophenoxy)methyl)-1-(piperidin-4-yl)-1H-pyrazole-5-carbonitrile

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1258001-22-7
tert-butyl 4-(5-bromo-4-ethoxycarbonylpyrazol-1-yl)piperidine-1-carboxylate

: 1258001-67-0
4-((2,5-difluorophenoxy)methyl)-1-(piperidin-4-yl)-1H-pyrazole-5-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 15 h / 0 - 20 °C / Reflux

1.2: 0.33 h / 20 °C / Cooling with ice

2.1: N,N-dimethyl-formamide / 4 h / 165 °C

3.1: triethylamine / dichloromethane / 4.5 h / 20 °C

4.1: caesium carbonate / acetonitrile / 15 h / Reflux

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h / 20 °C

With hydrogenchloride; dimethylsulfide borane complex; caesium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1258001-67-0
4-((2,5-difluorophenoxy)methyl)-1-(piperidin-4-yl)-1H-pyrazole-5-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 19 h / 0 - 20 °C

2.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 2.75 h / -78 - -10 °C

2.2: 20 h / -10 - 20 °C

3.1: triethylamine / dichloromethane / 4.5 h / 20 °C

4.1: caesium carbonate / acetonitrile / 15 h / Reflux

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h / 20 °C

With hydrogenchloride; diisobutylaluminium hydride; caesium carbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene; acetonitrile;