2-Fluoro-4-methoxyphenylboronic acid

Base Information

• Chemical Name: 2-Fluoro-4-methoxyphenylboronic acid
• CAS No.: 162101-31-7
• Molecular Formula: C₇H₈BFO₃
• Molecular Weight: 169.948
• Hs Code.: 2931900090
• Mol file: 162101-31-7.mol

Synonyms:Boronicacid, (2-fluoro-4-methoxyphenyl)- (9CI);

Chemical Property of 2-Fluoro-4-methoxyphenylboronic acid

Chemical Property:

• Appearance/Colour: off-white solid
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.504
• Boiling Point: 291.169 °C at 760 mmHg
• PKA: 8.75±0.58(Predicted)
• Flash Point: 129.895 °C
• PSA: 49.69000
• Density: 1.265 g/cm³
• LogP: -0.48590
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: soluble in Methanol

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoro-4-methoxybenzeneboronicacid 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-36-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: suzuki reaction

Technology Process of 2-Fluoro-4-methoxyphenylboronic acid

There total 3 articles about 2-Fluoro-4-methoxyphenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

Trimethyl borate (121-43-7,63156-11-6) + 1-bromo-2-fluoro-4-methoxybenzene (458-50-4) → (2-fluoro-4-methoxyphenyl)boronic acid (162101-31-7)

Guidance literature:

1-bromo-2-fluoro-4-methoxybenzene; With n-butyllithium; In tetrahydrofuran; Inert atmosphere;

Trimethyl borate; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1002/anie.201510321

Reference yield:

Trimethyl borate (121-43-7,63156-11-6) + 1-bromo-2-fluoro-4-methoxybenzene (458-50-4) + water (7732-18-5) → (2-fluoro-4-methoxyphenyl)boronic acid (162101-31-7)

Guidance literature:

1-bromo-2-fluoro-4-methoxybenzene; With magnesium; In tetrahydrofuran; at 40 ℃; for 1h; Inert atmosphere;

Trimethyl borate; In tetrahydrofuran; at 5 - 20 ℃; Inert atmosphere;

water; With hydrogenchloride; In tetrahydrofuran;

Reference yield:

(3aR,4R,6R,7aS)-2-(2-fluoro-4-methoxyphenyl)-3a-(4-(2-(2-methoxyethoxy)ethoxy)butyl)-5,5-dimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborole → (1R,2R,3S,5R)-2-(4-(2-(2-methoxyethoxy)ethoxy)butyl)-6,6-dimethylbicyclo[3.1.1]heptane-2,3-diol + (2-fluoro-4-methoxyphenyl)boronic acid (162101-31-7)

Guidance literature:

In tetrahydrofuran; at 20 ℃; Equilibrium constant; Inert atmosphere;

DOI:10.1002/anie.201510321

upstream raw materials:

Trimethyl borate

1-bromo-2-fluoro-4-methoxybenzene

water

Refernces

• 1、 -. "Compound having fluorinated naphthalene structure and liquid crystal composition of the same". Page/Page column 37. . Retrieved 2016/05/19.