5-(2-fluoro-4-methoxyphenyl)-6-methyl-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-indazole

Base Information

Chemical Name:5-(2-fluoro-4-methoxyphenyl)-6-methyl-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-indazole
CAS No.:1467061-53-5
Molecular Formula:C₂₁H₂₇FN₂O₂Si
Molecular Weight:386.541
Hs Code.:

Synonyms:5-(2-fluoro-4-methoxyphenyl)-6-methyl-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-indazole

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Chemical Property of 5-(2-fluoro-4-methoxyphenyl)-6-methyl-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-indazole

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Technology Process of 5-(2-fluoro-4-methoxyphenyl)-6-methyl-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-indazole

There total 3 articles about 5-(2-fluoro-4-methoxyphenyl)-6-methyl-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1467061-52-4
5-bromo-6-methyl-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-indazole

: 162101-31-7
(2-fluoro-4-methoxyphenyl)boronic acid

: 1467061-53-5
5-(2-fluoro-4-methoxyphenyl)-6-methyl-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-indazole

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 90 ℃; for 0.666667h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 885223-72-3
5-bromo-6-methyl-1H-indazole

: 1467061-53-5
5-(2-fluoro-4-methoxyphenyl)-6-methyl-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-indazole

Guidance literature:: Multi-step reaction with 2 steps

1: dicyclohexylmethylamine / tetrahydrofuran / 3 h / 20 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / water; 1,4-dioxane / 0.67 h / 90 °C / Inert atmosphere; Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dicyclohexylmethylamine; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1467061-53-5
5-(2-fluoro-4-methoxyphenyl)-6-methyl-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-indazole

Guidance literature:: Multi-step reaction with 2 steps

1: dicyclohexylmethylamine / tetrahydrofuran / 3 h / 20 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / water; 1,4-dioxane / 0.67 h / 90 °C / Inert atmosphere; Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dicyclohexylmethylamine; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; water;