2-chloro-1-(5-(3-nitrophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethanone

Base Information

Chemical Name:2-chloro-1-(5-(3-nitrophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethanone
CAS No.:1341231-54-6
Molecular Formula:C₁₇H₁₄ClN₃O₃
Molecular Weight:343.769
Hs Code.:

Synonyms:2-chloro-1-(5-(3-nitrophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethanone

Suppliers and Price of 2-chloro-1-(5-(3-nitrophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-chloro-1-(5-(3-nitrophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethanone

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-chloro-1-(5-(3-nitrophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethanone

There total 4 articles about 2-chloro-1-(5-(3-nitrophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 614-48-2,24721-24-2
3-nitrochalcone

: 79-04-9
chloroacetyl chloride

: 1341231-54-6
2-chloro-1-(5-(3-nitrophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethanone

Guidance literature:: 3-nitrochalcone; With hydrazine hydrate; In chloroform; at 80 ℃; for 12h;

With potassium carbonate; In chloroform; for 0.25h; Cooling with ice;

chloroacetyl chloride; In chloroform; at 20 ℃; for 12h; Cooling with ice;
DOI:10.1016/j.bioorg.2021.105350

Reference yield: 58.0%

: 614-48-2,24721-24-2
3-nitrochalcone

: 79-11-8
chloroacetic acid

: 1341231-54-6
2-chloro-1-(5-(3-nitrophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethanone

Guidance literature:: With hydrazine hydrate; In ethanol; for 24h; Reflux;
DOI:10.1515/HC.2011.013

Reference yield:

: 98-86-2
acetophenone

: 1341231-54-6
2-chloro-1-(5-(3-nitrophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / ethanol; water / 5 h / 20 °C / Cooling with ice

2.1: hydrazine hydrate / chloroform / 12 h / 80 °C

2.2: 0.25 h / Cooling with ice

2.3: 12 h / 20 °C / Cooling with ice

With hydrazine hydrate; sodium hydroxide; In ethanol; chloroform; water; 1.1: |Claisen-Schmidt Condensation;
DOI:10.1016/j.bioorg.2021.105350