(4S,5R)-4-(4-Fluoro-phenyl)-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester

Base Information

Chemical Name:(4S,5R)-4-(4-Fluoro-phenyl)-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester
CAS No.:143527-64-4
Molecular Formula:C₁₇H₂₂FNO₅
Molecular Weight:339.364
Hs Code.:

Synonyms:(4S,5R)-4-(4-Fluoro-phenyl)-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester

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Chemical Property of (4S,5R)-4-(4-Fluoro-phenyl)-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester

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Technology Process of (4S,5R)-4-(4-Fluoro-phenyl)-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester

There total 18 articles about (4S,5R)-4-(4-Fluoro-phenyl)-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 154306-86-2
(4S,5R)-4-(4-Fluoro-phenyl)-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-methyl ester

: 143527-64-4
(4S,5R)-4-(4-Fluoro-phenyl)-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester

Guidance literature:: With lithium hydroxide; In ethanol; water; at 20 ℃; for 2h;
DOI:10.1016/S0040-4039(00)61724-0

Reference yield:

: 154306-84-0
methyl (2R,3S)-2-hydroxy-3-[(S)-1-phenyl]ethylamino-3-(4-fluorophenyl)propionate

: 143527-64-4
(4S,5R)-4-(4-Fluoro-phenyl)-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium/C 3percent / methanol; acetic acid / 4 h / 65 °C / 17841.6 Torr

2: Na₂CO₃ / CH₂Cl₂ / 72 h / 20 °C

3: 78 percent / pyridinium paratoluenesulfonate / toluene / 80 °C

4: 92 percent / LiOH / ethanol; H₂O / 2 h / 20 °C

With lithium hydroxide; hydrogen; pyridinium p-toluenesulfonate; sodium carbonate; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water; acetic acid; toluene;
DOI:10.1016/S0040-4039(00)61724-0

Reference yield:

: 154306-83-9
(3R,4S)-3-hydroxy-4-(4-fluorophenyl)-1-[(S)-1-phenyl]ethyl-2-azetidinone

: 143527-64-4
(4S,5R)-4-(4-Fluoro-phenyl)-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / hydrogen chloride gas / 2.5 h / 40 °C

2: hydrogen / palladium/C 3percent / methanol; acetic acid / 4 h / 65 °C / 17841.6 Torr

3: Na₂CO₃ / CH₂Cl₂ / 72 h / 20 °C

4: 78 percent / pyridinium paratoluenesulfonate / toluene / 80 °C

5: 92 percent / LiOH / ethanol; H₂O / 2 h / 20 °C

With hydrogenchloride; lithium hydroxide; hydrogen; pyridinium p-toluenesulfonate; sodium carbonate; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water; acetic acid; toluene;
DOI:10.1016/S0040-4039(00)61724-0