N-[5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide formate salt

Base Information

• Chemical Name: N-[5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide formate salt
• CAS No.: 1040721-09-2
• Molecular Formula: CH₂O₂*C₁₉H₂₅ClN₄O
• Molecular Weight: 406.912
• Mol file: 1040721-09-2.mol

Synonyms:N-[5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide formate salt

Chemical Property of N-[5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide formate salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide formate salt

There total 7 articles about N-[5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide formate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formic acid (64-18-6) + 5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-ylamine (1040724-41-1) + C12H19N3O → N-[5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide formate salt (1040721-09-2)

Guidance literature:

5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-ylamine; C₁₂H₁₉N₃O; In 1,2-dichloro-ethane; at 50 ℃; for 10h;

formic acid; In water; acetonitrile; for 0.166667h;

DOI:10.1016/j.ejmech.2014.03.031

Reference yield:

4-chloro-2-methylbenzoic acid (7499-07-2) → N-[5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide formate salt (1040721-09-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sulfuric acid / Reflux

2.1: n-butyllithium / acetonitrile; toluene; hexane / 0.33 h / -78 - 20 °C / Inert atmosphere

3.1: hydrazine hydrate / ethanol / 18 h / Reflux

4.1: 1,2-dichloro-ethane / 10 h / 50 °C

4.2: 0.17 h

With n-butyllithium; sulfuric acid; hydrazine hydrate; In ethanol; hexane; 1,2-dichloro-ethane; toluene; acetonitrile;

DOI:10.1016/j.ejmech.2014.03.031

Reference yield:

3-(4-chloro-2-methylphenyl)-3-oxopropanenitrile (1205055-78-2) → N-[5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide formate salt (1040721-09-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrazine hydrate / ethanol / 18 h / Reflux

2.1: 1,2-dichloro-ethane / 10 h / 50 °C

2.2: 0.17 h

With hydrazine hydrate; In ethanol; 1,2-dichloro-ethane;

DOI:10.1016/j.ejmech.2014.03.031

upstream raw materials:

4-chloro-2-methylbenzoic acid

3-(4-chloro-2-methylphenyl)-3-oxopropanenitrile

(piperidinyl-1)-4 butanoate d'ethyle

4-piperidin-1-ylbutanoic acid