N-(2-Amino-4-fluorophenyl)-2-chloropropanamide

Base Information

Chemical Name:N-(2-Amino-4-fluorophenyl)-2-chloropropanamide
CAS No.:868771-38-4
Molecular Formula:C₉H₁₀ClFN₂O
Molecular Weight:216.643
Hs Code.:
DSSTox Substance ID:DTXSID001247362
Nikkaji Number:J2.234.310F

Synonyms:N-(2-Amino-4-fluorophenyl)-2-chloropropanamide;868771-38-4;DTXSID001247362

Suppliers and Price of N-(2-Amino-4-fluorophenyl)-2-chloropropanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of N-(2-Amino-4-fluorophenyl)-2-chloropropanamide

Chemical Property:

XLogP3:1.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:216.0465688
Heavy Atom Count:14
Complexity:215

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C(=O)NC1=C(C=C(C=C1)F)N)Cl

Technology Process of N-(2-Amino-4-fluorophenyl)-2-chloropropanamide

There total 3 articles about N-(2-Amino-4-fluorophenyl)-2-chloropropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 868771-27-1
2-chloro-N-(4-fluoro-2-nitro-phenyl)-propionamide

: 868771-38-4
N-(2-amino-4-fluoro-phenyl)-2-chloro-propionamide

Guidance literature:: With iron; ammonium chloride; acetic acid; In water; N,N-dimethyl-formamide; at 50 ℃; for 0.25h;
DOI:10.3987/COM-05-10461

Reference yield:

: 21262-04-4
2-chloro-N-(4-fluorophenyl)propanamide

: 868771-38-4
N-(2-amino-4-fluoro-phenyl)-2-chloro-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / KNO₃ / H₂SO₄ / 1 h / 20 °C

2: 90 percent / Fe; NH₄Cl; AcOH / H₂O; dimethylformamide / 0.25 h / 50 °C

With iron; ammonium chloride; acetic acid; potassium nitrate; In sulfuric acid; water; N,N-dimethyl-formamide;
DOI:10.3987/COM-05-10461

Reference yield:

: 371-40-4
4-fluoroaniline

: 868771-38-4
N-(2-amino-4-fluoro-phenyl)-2-chloro-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 98.5 percent / toluene / 1 h / 120 °C

2: 95 percent / KNO₃ / H₂SO₄ / 1 h / 20 °C

3: 90 percent / Fe; NH₄Cl; AcOH / H₂O; dimethylformamide / 0.25 h / 50 °C

With iron; ammonium chloride; acetic acid; potassium nitrate; In sulfuric acid; water; N,N-dimethyl-formamide; toluene;
DOI:10.3987/COM-05-10461