1-acetyl-5-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole

Base Information

Chemical Name:1-acetyl-5-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole
CAS No.:1239732-90-1
Molecular Formula:C₂₆H₂₀ClFN₄O
Molecular Weight:458.922
Hs Code.:

Synonyms:1-acetyl-5-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole

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Chemical Property of 1-acetyl-5-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole

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Technology Process of 1-acetyl-5-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole

There total 6 articles about 1-acetyl-5-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1239732-61-6
(E)-3-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-1-(4-fluorophenyl)-prop-2-en-1-one

: 64-19-7,77671-22-8
acetic acid

: 1239732-90-1
1-acetyl-5-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole

Guidance literature:: With hydrazine hydrate; for 0.0833333h; Microwave irradiation;
DOI:10.1016/j.bmc.2010.06.013

Reference yield: 84.0%

: 380450-08-8
C₂₄H₁₆ClFN₂O

: 64-19-7,77671-22-8
acetic acid

: 1239732-90-1
1-acetyl-5-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole

Guidance literature:: With hydrazine hydrate; at 70 - 75 ℃;
DOI:10.1016/j.bmcl.2013.02.105

Reference yield:

: 100-63-0
phenylhydrazine

: 1239732-90-1
1-acetyl-5-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / methanol / 4 h / 70 °C

2: trichlorophosphate / 5 h / 80 °C

3: sodium hydroxide / 1 h / 40 - 50 °C

4: hydrazine hydrate / 70 - 75 °C

With sulfuric acid; hydrazine hydrate; sodium hydroxide; trichlorophosphate; In methanol; 2: |Vilsmeier-Haack Formylation;
DOI:10.1016/j.bmcl.2013.02.105