139745-90-7Relevant academic research and scientific papers
AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE
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Paragraph 0540-0541, (2014/08/19)
The present invention relates to the field of medicine. Provided herein are aminoquinazoline derivatives, their salts and pharmaceutical formulations useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. Also provided herein are pharmaceutically acceptable compositions comprising the aminoquinazoline compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.
Stereoselective synthesis of swainsonines from pyridines
Heimg?rtner, Gerres,Raatz, Dirk,Reiser, Oliver
, p. 643 - 655 (2007/10/03)
An efficient synthesis of (-)-swainsonine and (-)-2,8a-di-epi-swainsonine was developed starting from readily available 2-pyridinecarbaldehyde and 3-hydroxypyridine. In particular, it was demonstrated that the mixture of simple indolizidines, i.e. lentigi
Synthesis and binding properties to GABA receptors of 3-hydroxypyridinyl- and 3-hydroxypiperidinyl-analogues of baclofen
Desideri,Galli,Sestili,Stein
, p. 29 - 33 (2007/10/02)
The synthesis of 3-(3-hydroxy-2-pyridinyl)propanoic acid, 3-(3-hydroxy-2-pyridinyl)-4-aminobutanoic acid, their corresponding piperidine compounds, and of some cyclized derivatives is described. In vitro assays none of the new compounds shows any notewort
