(S)-3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester

Base Information Edit

Chemical Name:(S)-3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester
CAS No.:109721-08-6
Molecular Formula:C12H24 O5 Si
Molecular Weight:276.405
Hs Code.:2931900090
Mol file:109721-08-6.mol

Synonyms:Pentanedioicacid, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, monomethyl ester, (3S)-(9CI); Pentanedioic acid, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-,monomethyl ester, (S)-; Monomethyl (S)-3-(tert-butyldimethylsilyloxy)glutarate

Suppliers and Price of (S)-3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 6 raw suppliers

Chemical Property of (S)-3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester Edit

Chemical Property:

PSA：72.83000
LogP:2.41460

Purity/Quality:: 99% ^*data from raw suppliers

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MSDS Files:: SDS file from LookChem

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General Description (S)-3-[[(1,1-Dimethyl)dimethylsilyl]oxy]pentanedioic acid monomethyl ester is an enantiomeric intermediate structurally related to (R)-3-TBDMSO glutaric acid methyl monoester, which is a key precursor in the synthesis of rosuvastatin. While the literature focuses on the enzymatic production and optimization of the (R)-enantiomer, the (S)-enantiomer is its stereochemical counterpart, differing only in the configuration at the chiral center. The (R)-enantiomer has been successfully synthesized using engineered lipases like Candida antarctica lipase B (CALB) mutants or Novozym 435 under mild, green conditions, achieving high enantioselectivity and yield. The (S)-enantiomer would likely exhibit similar physicochemical properties but would require enantioselective synthesis methods favoring the (S)-configuration. Its applications may mirror those of the (R)-form, though its biological or pharmaceutical relevance would depend on specific stereochemical requirements.

Technology Process of (S)-3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester

There total 2 articles about (S)-3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

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