3-[(4-Fluorophenyl)carbonyl]piperidine hydrochloride

Base Information

• Chemical Name: 3-[(4-Fluorophenyl)carbonyl]piperidine hydrochloride
• CAS No.: 118412-66-1
• Molecular Formula: C₁₂H₁₄FNO*ClH
• Molecular Weight: 243.709
• European Community (EC) Number: 826-181-3
• Mol file: 118412-66-1.mol

Synonyms:118412-66-1;3-[(4-fluorophenyl)carbonyl]piperidine hydrochloride;3-(4-fluorobenzoyl)piperidine hydrochloride;(4-fluorophenyl)-piperidin-3-ylmethanone;hydrochloride;(4-Fluorophenyl)-3-piperidinyl-methanone HCl;SCHEMBL5478791;ZJPKSFYBPAPDKL-UHFFFAOYSA-N;AKOS026672478;SB43171;BS-26388;CS-0209243;EN300-82518;F80301;3-[(4-fluorophenyl)carbonyl]piperidinehydrochloride;(RS)4-fluorophenyl-(3-piperidyl)methanone hydrochloride;Z1250132715

Chemical Property of 3-[(4-Fluorophenyl)carbonyl]piperidine hydrochloride

Chemical Property:

• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 243.0826200
• Heavy Atom Count: 16
• Complexity: 224

Purity/Quality:

95-99% ^*data from raw suppliers

3-[(4-Fluorophenyl)carbonyl]piperidineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CC(CNC1)C(=O)C2=CC=C(C=C2)F.Cl

Technology Process of 3-[(4-Fluorophenyl)carbonyl]piperidine hydrochloride

There total 1 articles about 3-[(4-Fluorophenyl)carbonyl]piperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(4-fluorophenyl)(3-pyridinyl)methanone (52779-56-3) → 3-(4-fluorobenzoyl)piperidin-1-ium chloride (118412-66-1)

Guidance literature:

(4-fluorophenyl)(3-pyridinyl)methanone; With N,N,N,N,N,N-hexamethylphosphoric triamide; In dichloromethane; at 25 ℃; for 0.166667h; Inert atmosphere;

With trichlorosilane; In dichloromethane; at 25 ℃; for 24h; Inert atmosphere;

DOI:10.3390/molecules24030401

Reference yield: 53.0%

3-(4-fluorobenzoyl)piperidin-1-ium chloride (118412-66-1) + 4-fluorobenzoyl chloride (403-43-0) → 1-(4-fluorobenzoyl)-3-(4-fluorobenzoyl)piperidine

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

3-(4-fluorobenzoyl)piperidin-1-ium chloride (118412-66-1) + 4-fluoroaniline (371-40-4) → N,α-bis(4-Fluorophenyl)-3-piperidinemethanamine (1238965-37-1)

Guidance literature:

upstream raw materials:

(4-fluorophenyl)(3-pyridinyl)methanone

Downstream raw materials:

N,α-bis(4-Fluorophenyl)-3-piperidinemethanamine

Refernces