(1R)-2-tert-butoxy-1-methyl-2-oxoethyl (2R)-2-(5-chloro-2-iodoanilino)-4-oxobutanoate

Base Information

Chemical Name:(1R)-2-tert-butoxy-1-methyl-2-oxoethyl (2R)-2-(5-chloro-2-iodoanilino)-4-oxobutanoate
CAS No.:252349-38-5
Molecular Formula:C₁₇H₂₁ClINO₅
Molecular Weight:481.715
Hs Code.:

Synonyms:(1R)-2-tert-butoxy-1-methyl-2-oxoethyl (2R)-2-(5-chloro-2-iodoanilino)-4-oxobutanoate

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Chemical Property of (1R)-2-tert-butoxy-1-methyl-2-oxoethyl (2R)-2-(5-chloro-2-iodoanilino)-4-oxobutanoate

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Technology Process of (1R)-2-tert-butoxy-1-methyl-2-oxoethyl (2R)-2-(5-chloro-2-iodoanilino)-4-oxobutanoate

There total 7 articles about (1R)-2-tert-butoxy-1-methyl-2-oxoethyl (2R)-2-(5-chloro-2-iodoanilino)-4-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 476689-67-5
(1R)-2-(tert-butoxy)-1-methyl-2-oxoethyl (2R)-2-(5-chloro-2-iodoanilino)-4-pentenoate

: 252349-38-5
(1R)-2-tert-butoxy-1-methyl-2-oxoethyl (2R)-2-(5-chloro-2-iodoanilino)-4-oxobutanoate

Guidance literature:: (1R)-2-(tert-butoxy)-1-methyl-2-oxoethyl (2R)-2-(5-chloro-2-iodoanilino)-4-pentenoate; With ozone; In dichloromethane; at -78 ℃;

With triphenylphosphine; In dichloromethane; for 2h; Further stages.;
DOI:10.1021/jo020327d

Reference yield:

: 6213-94-1
trimethylsiloxyethene

: 476689-66-4
tert-butyl-(2R)-2-({(2E)-2-[(5-chloro-2-iodophenyl)imino]ethanoyl}oxy)propanoate

: 2-(5-chloro-2-iodo-phenylamino)-4-oxo-butyric acid 1-tert-butoxycarbonyl-ethyl ester

: 252349-38-5
(1R)-2-tert-butoxy-1-methyl-2-oxoethyl (2R)-2-(5-chloro-2-iodoanilino)-4-oxobutanoate

Guidance literature:: ytterbium(III) triflate; In dichloromethane; at -20 ℃; for 1h;
DOI:10.1016/j.bmcl.2006.12.022

Reference yield:

: 68166-83-6
D-lactic acid t-butyl ester

: 252349-38-5
(1R)-2-tert-butoxy-1-methyl-2-oxoethyl (2R)-2-(5-chloro-2-iodoanilino)-4-oxobutanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 88 percent / Et₃N; DMAP / CH₂Cl₂ / 3 h / 0 - 20 °C

2.1: 100 percent / OsO₄; NaIO₄ / tetrahydrofuran; H₂O / 12 h / 20 °C

3.1: 100 percent / toluene / 2 h / Heating

4.1: TiCl₄ / CH₂Cl₂; toluene / 0.33 h / -78 °C

4.2: 77 percent / CH₂Cl₂; toluene / 0.25 h / -78 °C

5.1: O₃ / CH₂Cl₂ / -78 °C

5.2: 55 percent / PPh₃ / CH₂Cl₂ / 2 h

With dmap; sodium periodate; osmium(VIII) oxide; titanium tetrachloride; ozone; triethylamine; In tetrahydrofuran; dichloromethane; water; toluene;
DOI:10.1021/jo020327d